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A tosylhydrazone in organic chemistry is a functional group with the general structure RR'C=N-NH-Ts where Ts is a tosyl group. Organic compounds having this functional group can be accessed by reaction of an aldehyde or ketone with tosylhydrazine. Synthesis As an example camphor tosylhydrazone is synthesised from camphor and tosylhydrazine in ethanol with hydrochloric acid catalysis. Reactions Hydrolysis is the reverse reaction of formation with regeneration of the carbonyl compound. In the Shapiro reaction tosylhydrazones are used as a leaving group in elimination reactions. This reaction requires a strong base. If sodium methoxide is used as the base the reaction is called a Bamford–Stevens reaction. Tosylhydrazones can be reduced to the corresponding alkanes with reagents such as sodium borohydride and borane. Tosylhydrazone salts can react with metals to form metal carbenes and used in cyclopropanations and epoxidations. An example of a transition metal-catalyzed cyclopropanation is a synthesis of tranylcypromine, in which the sodium salt of benzaldehyde tosylhydrazone is converted to a rhodium metal carbene through the diazo intermediate. Tosylhydrazones are also starting materials for certain cross-coupling reactions. In the first report on this reaction type the coupling partners were a tosylhydrazone, an aryl halide with catalyst system dibenzylideneacetone / XPhos. As part of the catalytic cycle the diazo intermediateformed by decomposition of the tosylhydrazone forms a palladium-carbene complex with the oxidative addition complex of palladium with the aryl halide. Using this powerful method it is possible to access bioactive compounds. References. Discover the Jeffery Richardson popular books. Find the top 100 most popular Jeffery Richardson books.

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  • In The Shadows synopsis, comments

    In The Shadows

    Gilles Boyer & Édouard Philippe

    Loved House of Cards?'Utterly fascinating.' Perlustra'Absolutely brilliant.' BertrandHe thought the worst was behind them. The primaries done and dusted. The Presidency within ar...