Who is Michael Lennington?

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Michael Lennington Biography & Facts

The rostral migratory stream (RMS) is a specialized migratory route found in the brain of some animals along which neuronal precursors that originated in the subventricular zone (SVZ) of the brain migrate to reach the main olfactory bulb (OB). The importance of the RMS lies in its ability to refine and even change an animal's sensitivity to smells, which explains its importance and larger size in the rodent brain as compared to the human brain, as our olfactory sense is not as developed. This pathway has been studied in the rodent, rabbit, and both the squirrel monkey and rhesus monkey. When the neurons reach the OB they differentiate into GABAergic interneurons as they are integrated into either the granule cell layer or periglomerular layer. Although it was originally believed that neurons could not regenerate in the adult brain, neurogenesis has been shown to occur in mammalian brains, including those of primates. However, neurogenesis is limited to the hippocampus and SVZ, and the RMS is one mechanism neurons use to relocate from these areas. Brief history The RMS was named and discovered by J. Altman in 1969 using 3H-thymidine autoradiography in the rat brain. He traced the migration of labeled cells from the SVZ, which is situated throughout the lateral walls of the lateral ventricles, rostrally to the main olfactory bulb. He also quantitatively studied the effect of age on the size of the RMS. There is still some ongoing debate about the extent of the RMS and adult SVZ neurogenesis of new neurons in humans. Cell biology Vascular cells Vascular cells are known to play a prominent role in regulating proliferation of adult neural precursors. In the adult subgranular zone (SGZ), dense clusters of dividing cells were found to be anatomically close to the vasculature, especially capillaries. Contacts between adult SVZ neuronal precursors and blood vessels are unusually permeable and frequently devoid of astrocyte and pericyte interferences, suggesting that blood-derived cues are gaining direct access to adult neural precursors and their progeny. The vasculature also provides the substrate for new neuron migration after injury in the adult striatum. In the RMS, vascular cells are arranged parallel to the route of the migrating cells and provide a scaffolding. Glial cells are also associated with the blood vessels; communication between these cells may be important for RMS migration, for example, in BDNF (brain-derived neurotrophic factor), a growth factor that is thought to module RMS migration. Astrocytes Astrocytes form gap junctions and are closely associated with the vasculature and its basal lamina in the adult SVZ and subsequently in the RMS. They may serve as an interface to modulate influences of endothelial and circulation-derived factors as well as the availability of cytokines and growth factors in this system. In addition, astrocytes derived from the neurogenic hippocampus and SVZ, but not from the non-neurogenic spinal cord, promote proliferation and neuronal fate commitment of multipotent adult neural stem cells in culture, suggesting a role in the RMS. Astrocytes express a number of secreted and membrane-attached factors both in vitro and in vivo that are known to regulate proliferation and fate specification of adult neural precursors as well as neuronal migration, maturation, and synapse formation. In the adult SVZ, astrocytes express Robo receptors and regulate the rapid migration of SLIT1-expressing neuroblasts through the RMS. Additionally, it has been proposed that the neuroblasts themselves play a role in modulating the astrocytes through Slit-Robo interactions. In the absence of Slit, astrocytic processes do not align correctly, or create the "tubes", instead running across the migrating neurons. Adult SVZ astrocytes also appear to release glutamate to regulate the survival of neuroblasts. Unique to the adult SVZ, ependymal cells lining the ventricular wall are in close association with neural precursors and their progeny, acting like a shield to protect the "neurogenic niche", a zone in which stem cells are retained after embryonic development for the production of new cells of the nervous system. Other glial cells Ependymal cells actively regulate neuronal fate specification of adult neural precursors through release of Noggin. Beating of the cilia of ependymal cells appears to set up concentration gradients of guidance molecules, such as cytokines TNF-α (tumor necrosis factor) and IGF-1 (insulin-like growth factor), to direct migration of neuroblasts, such as in the RMS. Microglia also actively regulate adult neurogenesis. Under basal conditions, apoptotic corpses of newly generated neurons are rapidly phagocytosed from the niche by unactivated microglia in the adult SGZ. Under inflammatory conditions, reactivated microglia can have both beneficial and detrimental effects on different aspects of adult neurogenesis, depending on the balance between secreted molecules with pro- and anti-inflammatory action. In one study, the activation of microglia and recruitment of T cells were suggested to be required for enriched environment-induced SGZ neurogenesis, suggesting a possible role in the RMS. Migration mechanics Cells in the RMS are believed to move by "chain migration". These neuroblasts are connected by membrane specializations including gap junctions and adherens junctions, moving along each other towards the olfactory bulb through glial tubes. The pathway and mechanisms behind this movement are a ventriculo-olfactory neurogenic system (VONS), a glial framework, and a chemotaxic cell signalling system. Ventriculo-olfactory neurogenic system (VONS) The olfactory system is made up in part of the RMS which stretches from the subventricular zone in the wall of the lateral ventricle, through the basal forebrain, to the olfactory bulb (OB). VONS is the name given to this pathway, and it consists of the subventricular zone, the RMS, the olfactory tract and the olfactory bulb. Developing neurons leave the subventricular zone and enter the RMS and travel caudally and ventrally along the undersurface of the caudate nucleus; this is referred to as the descending limb. Upon reaching the ventral side of the caudate nucleus, the neurons follow the rostral limb and travel ventrally and rostrally, entering the anterior olfactory cortex (AOC). The AOC gives rise to the olfactory tract, which ends in the olfactory bulb. Glial framework Developing neurons travel toward the olfactory bulb along the RMS via glial tubes, which mark the division between the differentiated nervous tissue and the tissue with embryonic characteristics. Uniquely, the cells travel tangential to the brain surface, parallel to the pial surfaces rather than radially like most developing neurons. Neurons that migrate tangentially are typically believed to migrate independently of radial glia but in the RMS researchers believe this is not the case. Adult rat glial tubes have bee.... Discover the Michael Lennington popular books. Find the top 100 most popular Michael Lennington books.

Best Seller Michael Lennington Books of February 2023

Dead Before Dinner e-book Download

Dead Before Dinner

Kat BellemoreJuly 31, 2022Get

Green chile has never been more dangerous.   Psychologist Maddie Swallows’ decision to return to New Mexico seemed like a good idea at the time, considering the divorce and her two te...

Seduction Island e-book Download

Seduction Island

Autumn GazeNovember 30, 2022Get

You cannot escape the reality of tomorrow by evading it today… Ethan Mitchell flees New York to Oahu to escape a family scandal. He doesn't want to be a part of it. He ends up meeting Ava ...

Law of Attraction e-book Download

Law of Attraction

Jordan HollisAugust 29, 2018Get

How to Finally Overcome the Hurdles of Manifesting Proven, effective and enjoyable ways to help you manifest faster… Right now, think of something that makes you successful. If you have so...

Dream Psychology e-book Download

Dream Psychology

Sigmund FreudNovember 1, 1899Get

An Apple Books Classic edition. Written by the founding father of psychoanalysis, Sigmund Freud’s 1899 book is the definitive text on learning to interpret dreams. Freud’s groundbreaking...

Kingdoms of Sand: Books 1-3 e-book Download

Kingdoms of Sand: Books 1-3

Daniel ArensonOctober 23, 2018Get

Game of Thrones  meets  Spartacus  in an epic saga of sand and splendor. This bundle contains the first three novels of  Kingdoms of Sand , a fantasy series from a  ...

Today I Am Mad e-book Download

Today I Am Mad

Michael GordonSeptember 7, 2020Get

Kids feel emotions in big ways! Here's a great story for helping kids manage their feelings. * Help children learn to identify and regulate their ...

Finding Cinderella e-book Download

Finding Cinderella

Colleen HooverOctober 14, 2013Get

#1 New York Times bestselling author of It Starts with Us and It Ends With Us writes a free novella about the search for happily ever after. A chance encounter in the dark leads eighteen-yea...

Worth Billions e-book Download

Worth Billions

Lexy TimmsJune 4, 2018Get

Small towns are for small minds. I left for college and never looked back.  Ensconced in my luxurious, and lucrative, vineyard, I barely ever spare a thought for my old life. Until I go...

Fat Cat Finds a Home e-book Download

Fat Cat Finds a Home

Michelle SmithFebruary 20, 2015Get

After ten years of love from her previous owner, poor Fat Cat finds herself alone and looking for a new home. Will she ever leave the adoption shelter? Even at ten years old, Fat Cat still h...

How to Find Peace e-book Download

How to Find Peace

Beau NortonSeptember 23, 2015Get

Shatter the Illusions and Discover the Truth To 'know about' something is very different from KNOWING it. Perhaps you have some spiritual knowledge, but how often do you experience ...

How to Win Friends and Influence People e-book Download

How to Win Friends and Influence People

Dale CarnegieJuly 7, 2022Get

How to Win Friends and Influence People is a self-help book written by Dale Carnegie, first published in 1936. Over 30 million copies have been sold worldwide, making it one of the best-sell...

The Chronicles of Narnia Complete 7-Book Collection e-book Download

The Chronicles of Narnia Complete 7-Book Collection

C. S. LewisDecember 9, 2022Get

The Chronicles of Narnia Complete 7-Book Collection includes: The Lion, the Witch and the Wardrobe (1950) Prince Caspian (1951) The Voyage of the Dawn Treader (1952) The Silver Chair (1953) ...

Shiftless e-book Download

Shiftless

Aimee EasterlingOctober 24, 2014Get

Terra is shiftless --- a werewolf uncomfortable in her own animal skin. A decade after learning to squash her wolf and flee the repressive village where she grew up, the packless ache still ...

Girl, Alone (An Ella Dark FBI Suspense Thriller—Book 1) e-book Download

Girl, Alone (An Ella Dark FBI Suspense Thriller—Book 1)

Blake PierceDecember 16, 2020Get

FBI Agent Ella Dark has studied serial killers from the time she could read, devastated by the murder of her own sister. With her photographic memory, she has obtained an encyclopedic knowle...

iPad User Guide e-book Download

iPad User Guide

Apple Inc.October 24, 2022Get

Here’s everything you need to know about iPad, straight from Apple. This definitive guide helps you get started using iPad with iPadOS 16 and discover all the amazing things it can do.

How to Think Bigger: Aim Higher, Get More Motivated, and Accomplish Big Things e-book Download

How to Think Bigger: Aim Higher, Get More Motivated, and Accomplish Big Things

Martin MeadowsAugust 4, 2015Get

How to Get More Motivated, Set Bigger Goals, and Achieve More by Thinking Bigger Have you ever wondered what separates people who think bigger from people who set their bar low? What makes o...

The Very Hungry Caterpillar Library Books 1.1 e-book Download

The Very Hungry Caterpillar Library Books 1.1

Eric CarleMay 24, 2017Get

This is the series of The Very Hungry Caterpillar Little Learning Library Books. This book with Audio has been created as a university project for my last year. I have created lyrics and mus...

Mistletoe Madness: A Sweet Small Town Christmas Romance (Santa's Secret Helpers, Book 2) e-book Download

Mistletoe Madness: A Sweet Small Town Christmas Romance (Santa's Secret Helpers, Book 2)

Leeanna MorganApril 21, 2020Get

Fans of Robyn Carr's Virgin River series will love this small-town, feel-good romance! This Christmas, something magical is happening in Sapphire Bay. Kylie loves everything about Christmas....

The Complete Works of Edgar Allan Poe (Illustrated, Inline Footnotes) e-book Download

The Complete Works of Edgar Allan Poe (Illustrated, Inline Footnotes)

Edgar Allan PoeSeptember 16, 2016Get

The Novels of Edgar Allan Poe. • Narrative Of A. Gordon Pym. (Inline Footnotes) • The Journal Of Julius Rodman. (Illustrated / Inline Footnotes) The Complete Tales of Edgar Allan Poe. (I...

Pride and Prejudice e-book Download

Pride and Prejudice

Jane AustenJanuary 28, 1813Get

An Apple Books Classic edition. Jane Austen’s beloved classic opens with this witty and very memorable line: “It is a truth universally acknowledged, that a single man in possession of a...

I Have a Secret e-book Download

I Have a Secret

Cheryl BradshawApril 25, 2012Get

"The ending is a complete surprise!" - Reader  Doug Ward has been running from his past for twenty years. But after his fourth whisky of the night, his steely resolve has started to cra...

The Art Of Letting Go e-book Download

The Art Of Letting Go

Thought CatalogFebruary 29, 2016Get

We often struggle to let some people go especially when they made that decision. We question the universe, we question ourselves and we question everyone around us but we never truly get our...

The Chase e-book Download

The Chase

Elle KennedyAugust 6, 2018Get

New York Times bestseller! The first book in a new series from international bestselling author Elle Kennedy!  Everyone says opposites attract. And they must be right, because there’s...

Stealth e-book Download

Stealth

Sarah PeisApril 28, 2022Get

Some mistakes are worth repeating. Freya Olysses loves her quiet life in the sleepy little town of Ferguson. She's made a home where she least expected to. Until her past catches up with her...

The Hunted e-book Download

The Hunted

A.J. ScudiereJune 20, 2019Get

Lights out. Keep still. Pray for morning. Joule and Cage Mazur feel like prisoners in their home. With something new stalking the streets at night, their family’s only protection is boltin...

Investing For Beginners e-book Download

Investing For Beginners

David CohneJuly 13, 2015Get

The Best Guide to Getting Started Investing You’ll Find Anywhere What Does Your Retirement Look Like? If you are like most Americans, you don’t know how you’re are going to retire. Pen...

Manifesting Abundance: How to Manifest Your Desires Using the Law of Attraction e-book Download

Manifesting Abundance: How to Manifest Your Desires Using the Law of Attraction

Beau NortonSeptember 26, 2015Get

Did you know that up to 95% of the people that attempt to use the law of attraction to manifest their desires see no noticeable results? The truth is that most people fail to use the law of ...

Complicate Me: Reid & Sienna #1 e-book Download

Complicate Me: Reid & Sienna #1

Claire RayeJuly 8, 2020Get

Complicate Me is book one of Reid and Sienna’s duet and book one in the Hawthorn Hills Duet Series. A two-part, angst-filled, slow-burn, epic love story. Complicate Me must be read before ...

Brant e-book Download

Brant

Jodi BasyeFebruary 14, 2022Get

He's a cranky cowboy trying to save the family ranch. She's a freelance journalist hoping to get a full-time writing gig. What she writes could either make or break him. Brant Cross feels re...

Watch Me e-book Download

Watch Me

Stacey KennedySeptember 15, 2020Get

In the Phoenix club, there is only one rule; watch, don't touch, until the powerful owner falls for his new star in this deliciously intriguing romance from USA Today bestselling author Stac...

Frankenstein e-book Download

Frankenstein

Mary ShelleyDecember 31, 1817Get

An Apple Books Classic edition. Mary Shelley was just 18 when she had a nightmare vision: “I saw the pale student of unhallowed arts kneeling beside the thing he had put together. I saw th...

The Art of Logical Thinking e-book Download

The Art of Logical Thinking

William Walker AtkinsonFebruary 28, 2013Get

Atkinson talks about successful pedagogical approach, guiding through the fundamental elements of formal deductive logic, classification and definition, fallacies, basic argument analysis, i...

Tempting Levi e-book Download

Tempting Levi

Jules BarnardJune 6, 2017Get

Off-limits never looked so tempting... Levi Cade’s firefighting career burned up after an accident on the job. Then is father died and left him in charge of the family’s multimillion-dol...

10-Minute Social Psychology e-book Download

10-Minute Social Psychology

Albert RutherfordJune 7, 2020Get

Would you like to instantly catch people's thoughts, emotions, motivations, and intentions through mere observation? If yes, you've come to the right place!  10-Minute So...

Alice's Adventures in Wonderland e-book Download

Alice's Adventures in Wonderland

Lewis CarrollNovember 25, 1865Get

An Apple Books Classic edition. Fall down the proverbial rabbit hole with Alice, the intrepid heroine of Lewis Carroll’s classic fantasy! When Alice spies a talking rabbit, she can’t res...

Holy Bible e-book Download

Holy Bible

The Church of Jesus Christ of Latter-day SaintsMarch 1, 2013Get

The 2013 edition of the Holy Bible contains all of the study aids contained in the 1979 edition and includes revisions to the study aids, several new photos, updated maps, and adjustments to...

Dirty Wild Sultan - A Steamy Marriage of Convenience Royal Romance e-book Download

Dirty Wild Sultan - A Steamy Marriage of Convenience Royal Romance

Mahi MistryJuly 7, 2022Get

He is my only chance at freedom. She is the daughter of my enemy. Will their love survive? Zain As the Sultan of one of the most powerful country in Middle-East, I need to find my Sultana. B...

The Adventures of Sherlock Holmes e-book Download

The Adventures of Sherlock Holmes

Arthur Conan DoyleOctober 14, 1892Get

An Apple Books Classic You get not one, not two, but 25 gripping mysteries in Arthur Conan Doyle’s first of five collections of Sherlock Holmes short stories. Follow the brilliant and ecce...

What I Like About You e-book Download

What I Like About You

Kait NolanJuly 19, 2019Get

A horse-whispering loner After years as an Army Ranger, Sebastian Donnelly is content to be left alone with his horses. He's better with them than with...people. But that changes when his bo...

Baking Bad - A Cozy Mystery (With Dragons) e-book Download

Baking Bad - A Cozy Mystery (With Dragons)

Kim M. WattNovember 4, 2018Get

A tranquil village. A poisoned cupcake. A murdered vicar. A simple case - or it should be. But all clues point to the Toot Hansell Women's Institute, and Detective Inspector Adams is about t...

The Ultimate 7 Steps to Awaken Your Alpha Male: How to Conquer Negative Thinking, Become Fearless, Master Confidence, Improve Your Life, Follow Your Passion and Attract Women e-book Download

The Ultimate 7 Steps to Awaken Your Alpha Male: How to Conquer Negative Thinking, Become Fearless, Master Confidence, Improve Your Life, Follow Your Passion and Attract Women

Keith BraxtonJuly 21, 2015Get

It’s Time to Unleash the Alpha Male Within You! By the end of this book, I expect you to be able to hold your head up high, laugh at your own fears, embrace your passions, find your desire...

Meditations e-book Download

Meditations

Emperor of Rome Marcus AureliusDecember 25, 2008Get

Meditations is a series of personal writings by Marcus Aurelius, Roman Emperor 161–180 CE, setting forth his ideas on Stoic philosophy.

Herbs and Homicide e-book Download

Herbs and Homicide

Carly WinterJune 9, 2022Get

5 stars, Liz Konkel of Readers' Favorite: The story has an upbeat tone that is typical of the cozy genre though Winter adds a unique quality to it through the use of herbs. The characte...

Nowhere Safe (A Harley Cole FBI Suspense Thriller—Book 1) e-book Download

Nowhere Safe (A Harley Cole FBI Suspense Thriller—Book 1)

Kate BoldSeptember 1, 2022Get

“This is an excellent book… When you start reading, be sure you don’t have to wake up early!” —Reader review for The Killing Game FBI BAU special agent Harley Cole, as brilliant as...

The Farthest Star e-book Download

The Farthest Star

A.R. KnightSeptember 22, 2020Get

In the far future, a dormant android awakes on a vast starship to find humanity's last hopes rest with him. Launched to carry the human species across the galaxy, Starship's generati...

Fighter's Best Friend e-book Download

Fighter's Best Friend

A. Rivers & Alexa RiversJanuary 20, 2022Get

My best friend is hot, rich, and emotionally unavailable. Falling in love with him is the worst idea ever but try telling that to my heart. As a doctor who aced her way through medical schoo...

Little Women e-book Download

Little Women

Louisa May AlcottSeptember 29, 1868Get

An Apple Books Classic edition. Meet the Marches! Louisa May Alcott’s classic introduces us to four unforgettable sisters: beautiful Meg, tomboyish Jo, delicate Beth, and Amy, the indulged...

The Holy Bible - King James Version e-book Download

The Holy Bible - King James Version

King JamesAugust 30, 2012Get

Holy Bible King James Version Few Sample Paragraphs from The Holy Bible eBook, Genesis (OT) 1 Gen. 1 IN the beginning God created the heaven and the earth. 2 And the earth was without form, ...

The Wonderful Wizard of Oz e-book Download

The Wonderful Wizard of Oz

L. Frank BaumMay 17, 1900Get

An Apple Books Classic edition. You’ve seen the iconic 1939 movie, but do you know about the talking field mice, the Winkies, and the Witch of the North that appear in the original book? L...

Wuthering Heights e-book Download

Wuthering Heights

Emily BrontëNovember 30, 1847Get

An Apple Books Classic edition. If you’ve only ever seen Wuthering Heights on screen, you may have an image of Catherine and Heathcliff as the ultimate star-crossed lovers. But that’s ju...

Best Seller Michael Lennington Audio Books of February 2023

Maybe Someday (Unabridged) audiobook
Maybe Someday (Unabridged)Colleen Hoover$4.99

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The Subtle Art of Not Giving a F*ck audiobook
The Subtle Art of Not Giving a F*ckMark Manson$16.99

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Can't Hurt Me: Master Your Mind and Defy the Odds (Unabridged) audiobook
Can't Hurt Me: Master Your Mind and Defy the Odds (Unabridged)David Goggins$21.99

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The Body Keeps the Score: Brain, Mind, and Body in the Healing of Trauma (Unabridged) audiobook
The Body Keeps the Score: Brain, Mind, and Body in the Healing of Trauma (Unabridged)Bessel van der Kolk, M.D.$14.99

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Never Finished: Unshackle Your Mind and Win the War Within (Unabridged) audiobook
Never Finished: Unshackle Your Mind and Win the War Within (Unabridged)David Goggins$21.99

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Greenlights (Unabridged) audiobook
Greenlights (Unabridged)Matthew McConaughey$14.99

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Sapiens audiobook
SapiensYuval Noah Harari$16.99

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Scars and Stripes (Unabridged) audiobook
Scars and Stripes (Unabridged)Tim Kennedy$16.99

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Endure audiobook
EndureCameron Hanes$16.99

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Local Woman Missing audiobook
Local Woman MissingMary Kubica$4.99

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Harry Potter and the Chamber of Secrets audiobook
Harry Potter and the Chamber of SecretsJ.K. Rowling$25.99

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Demon Copperhead audiobook
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Tom Clancy Red Winter (Unabridged) audiobook
Tom Clancy Red Winter (Unabridged)Marc Cameron$14.99

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Harry Potter and the Sorcerer's Stone audiobook
Harry Potter and the Sorcerer's StoneJ.K. Rowling$25.99

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Mad Honey: A Novel (Unabridged) audiobook
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The Seven Husbands of Evelyn Hugo (Unabridged) audiobook
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The Art of Seduction (Unabridged) : An Indispensible Primer on the Ultimate Form of Power audiobook
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Start with Why: How Great Leaders Inspire Everyone to Take Action (Unabridged) audiobook
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Tomorrow, and Tomorrow, and Tomorrow: A novel (Unabridged) audiobook
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The Light We Carry: Overcoming in Uncertain Times (Unabridged) audiobook
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The End of the World is Just the Beginning audiobook
The End of the World is Just the BeginningPeter Zeihan$3.99

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Never Split the Difference audiobook
Never Split the DifferenceChris Voss & Tahl Raz$19.99

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Get Your Sh*t Together audiobook
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All Good People Here: A Novel (Unabridged) audiobook
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The Intelligent Investor Rev Ed. audiobook
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