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Deepak Thankappan Nair (born 25 October 1973) is an Indian Structural Biologist and a scientist at Regional Centre for Biotechnology. He is known for his studies on DNA and RNA polymerases. Deepak was a Ramanujan fellow of the Science and Engineering Research Board (2008–2013) and a recipient of the National BioScience Award for Career Development (Dept. of Biotechnology). The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, for his contributions to biological sciences in 2017. He was inducted as a fellow of the Indian National Science Academy (New Delhi, India) in December, 2022. Biography His parents are from the southern state of Kerala and he was born in Pune in the western state of Maharashtra on 25 October 1973, Deepak Nair went to school at the Jai Hind High School (Pimpri) and then later to the St. Vincents Junior College (Pune). He graduated with BSc in Chemistry from Fergusson College (1994) and completed his master's in biotechnology from the Savitribai Phule Pune University (1996). Subsequently, he enrolled for his doctoral studies at the National Institute of Immunology, India to secure a PhD in structural immunology in 2001. For his PhD he worked under the supervision of Dr. Dinakar Mashnu Salunke. Later, he moved to the US to complete his post-doctoral work in the laboratory of Prof. Aneel K. Aggarwal at the Mount Sinai Medical Center. He returned to India in 2007 to take up the position of an independent investigator at the National Centre for Biological Sciences . He worked in NCBS as Reader-F (2007–2013) and Associate Professor (2013–2014). In July 2014, he joined the Regional Centre for Biotechnology as an Associate professor, and was promoted to the position of Professor in July 2019. Research Deepak Nair has obtained new insight regarding the molecular mechanisms that determine the fidelity of the replication process in bacteria and flaviviruses. His laboratory has shed new light on the strategy utilized by DNA polymerases to prevent ribonucleotide incorporation (NAR, 2019, 47:10693). In 2018, his laboratory showed that pyrophosphate hydrolysis is an intrinsic and critical step in the DNA synthesis reaction catalyzed by DNA polymerases and this discovery was accorded breakthrough status by the journal Nucleic Acids Chemistry (NAR, 2018, 46:5875). Regarding the piggyBac transposase, his laboratory has shown that the dimerization through the Ring Finger Domain present at the C-terminus attenuates the excision activity of this enzyme (Biochemistry, 2018, 57:2913). He has discovered the mechanism employed by DNA polymerase IV to rescue replication stalled at damaged nucleotides with unprecedented efficiency and accuracy (Structure, 2014, 23:56–67). Nair has provided insight into how specialized DNA polymerases that participate in adaptive mutagenesis ensure achieve function (Nucleic Acids Research, 2013, 41:5104–5014; Acta Crystallogr D Biol Crystallogr. 2012 68:960-7, J Nucleic Acids. 2012:285481). His laboratory has shown how GTP binding to the viral RNA-dependent-RNA polymerase ensures accurate initiation of replication of the viral genome (Nucleic Acids Research, 2014, 42:2758–2573). In addition, he has shown that reactive oxygen species do play an important role in the antimicrobial activity of bactericidal antibiotics (Angew Chem Int Ed Engl. 2016 55:2397-400). In collaboration with D. N. Rao (Department of Biochemistry, IISc), his laboratory has also contributed towards understanding how proteins involved in the post-replicative repair of DNA mismatches function (Nucleic Acids Research, 2018, 46:256–266; PLoS One. 2010, 5:e13726). His laboratory has shown that the proofreading domain of the Pfprex DNA polymerase from Plasmodium falciparum is capable of removing misincorporated oxidized nucleotides from the primer (Sci Rep. 2020,10(1):11157) and translesion DNA synthesis past common oxidized template nucleotides (FEBS J., 2022 289:5218). Recently his laboratory has helped in the characterization of a monoclonal antibody that can neutralize different Variants-of-Concern of the SARS-CoV-2 virus (PLoS Pathog., 2022,18(12):e1010994). Using computational tools his laboratory has also identified possible inhibitors of the RNA-dependent-RNA polymerase (IUBMB Life., 2020, 72:2112) and proofreading exoribonuclease from SARS-CoV-2 (Int J Biol Macromol.,2021,168:272). His laboratory also provided the structure of P4A2, a broadly neutralizing anti-SARS-CoV-2 mAb, in complex with the Receptor-Binding-Domain of the Spike protein (Plos Path. 2022,e1010994) So far, he has been centrally involved in the deposition of 76 entries in the protein data bank, which is a repository of three-dimensional structures of biological macromolecules. As a post-doctoral fellow (Dec 2001– July 2007) he focused on understanding the structural basis of DNA lesion bypass by eukaryotic Y-family DNA polymerases using X-ray crystallography. Due to the action of a variety of agents, lesions are formed on DNA which interferes with normal replication and may also prove carcinogenic. Eukaryotes possess up to four specialized DNA polymerases that are able to synthesize DNA across these lesions and thus prevent the replication fork from stalling. Nair determined the crystal structure of the catalytic cores of two such polymerases, human DNA polymerase iota (hPolι) and yeast REV1 (yREV1) –in complex with DNA and incoming nucleotide. The structures of hPolι and yRev1 in complex with undamaged and damaged DNA has shown that these two polymerases prefer altered modes of base-pairing in the active site to facilitate lesion bypass (Nature, 2004, 430:377; Science, 2005, 309:2219; Structure, 2005, 13:1569; Structure, 2006, 14:749; Nat. Struct. Mol. Biol., 2006, 13:619; Structure, 2008, 16:239; Structure, 2009, 17:530). Both hPolι and yREV1 have unique active sites that facilitate the formation of non-Watson-Crick base pairs to achieve lesion bypass and rescue stalled replication. He also played a role in the determination of the structure of a third Y-family polymerase human DNA Polymerase kappa in its functional state (Mol. Cell, 2007, 25:601). In addition, he also participated in projects aimed at understanding the nature of interactions between the translational regulator Pumilio and non-cognate RNA targets (Structure, 2008, 16:549) and discerning the preference of hPolι for incorporating dGTP when the base of the templating nucleotide is thymine (Structure, 2009, 17:974). His doctoral thesis (July 1996 – Dec 2001) describes the crystallographic analysis of a panel of three murine monoclonal antibodies raised against the same promiscuous peptide antigen PS1 (HQLDPAFGANSTNPD). (J Immunol, 2000, 165:6949; J. Immunol, 2002, 168:2371). The comparison of the structure of the antibodies in their bound and unbound s.... Discover the Sanjeev Bagga Md popular books. Find the top 100 most popular Sanjeev Bagga Md books.

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  • THE STUTTERER synopsis, comments

    THE STUTTERER

    Sanjeev Bagga MD

    Whiskey, Squirrel & Lizzy are good friends. They are students in Minerva school. The three girls like Thathu a boy who stutters. Squirrel wants to become an actor. Lizzy wants ...

  • The End in Ladakh synopsis, comments

    The End in Ladakh

    Sanjeev Bagga MD

    Few people understand the lives of doctors, especially surgeons. It takes years of studying & training before a person can become a good surgeon. The life of a surgeon is full ...

  • Fight For Justice synopsis, comments

    Fight For Justice

    Sanjeev Bagga MD

    Poverty and deprivation were twin curses that Sohan Lal’s children faced growing up in Delhi. Sohan Lal was an honest lowly clerk, derisively called Minister of Garbage because he ...

  • An Eye For An Eye synopsis, comments

    An Eye For An Eye

    Sanjeev Bagga MD

    Dave Cohen a slick lawyer has been in hiding for the last five years. He is bidding his time. He has to kill the man who murdered his wife. He has to destroy the man who ordered th...

  • The Family Trial synopsis, comments

    The Family Trial

    Sanjeev Bagga MD

    Suraj & his wife Usha are dancing at the wedding reception of their only son Agasthya who married his girlfriend Shruti. Usha & Suraj have been estranged for twentytwo year...