David A Sinclair Matthew D Laplante Popular Books

David A Sinclair Matthew D Laplante Biography & Facts

David Andrew Sinclair (born June 26, 1969) is an Australian-American biologist and academic known for his research and controversial claims on aging and epigenetics. Sinclair is a professor of genetics at Harvard Medical School. Early life and education David Andrew Sinclair was born in Australia in 1969 and grew up in St Ives, New South Wales. Sinclair studied at the University of New South Wales, Sydney, obtaining a BSc in biochemistry with honours in 1991 and a Ph.D. in molecular genetics in 1995, focusing on gene regulation in yeast. He also won the Australian Commonwealth Prize. Career In 1993, he met Leonard P. Guarente, a Massachusetts Institute of Technology professor who studied yeast as a model of aging, when Guarente was on a lecture tour in Australia, and the meeting spurred Sinclair to apply for a post-doc position in Guarente's lab. In 1999, after four years of working as a postdoctoral researcher for Guarente, Sinclair was hired at Harvard Medical School. In 2003, his lab was small and struggling for funding. In 2004, Sinclair met with the philanthropist Paul F. Glenn who donated $5 million to Harvard to establish the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard, of which Sinclair became the founding director. He is no longer a director of this center. In 2004, Sinclair, along with Andrew Perlman, Christoph Westphal, Richard Aldrich, Richard Pops, and Paul Schimmel, founded Sirtris Pharmaceuticals. Sirtris was focused on developing Sinclair's research into activators of sirtuins, work that began in the Guarente lab. The company was specifically focused on resveratrol formulations and derivatives as activators of the SIRT1 enzyme; Sinclair became known for making statements about resveratrol like: "(It's) as close to a miraculous molecule as you can find. ... One hundred years from now, people may be taking these molecules on a daily basis to prevent heart disease, stroke, and cancer." Most of the anti-aging field was more cautious, especially with regard to what else resveratrol might do in the body and its lack of bioavailability. The company's initial product was called SRT501, and was a formulation of resveratrol. Sirtris went public in 2007 and was subsequently purchased and made a subsidiary of GlaxoSmithKline in 2008 for $720 million. Five years later, GSK shuttered the Sirtris program without successful drug development. Despite the clinical failures of resveratrol and its scientific debunking, Sinclair continues to endorse taking resveratrol. In 2006, Genocea Biosciences was founded based on work of Harvard scientist Darren E. Higgins around antigens that stimulate T cells and the use of these antigens to create vaccines; Sinclair was a co-founder. Genocea laid off most of its workforce in 2022 after presenting disappointing data at AACR In 2008, Sinclair was promoted to tenured professor at Harvard Medical School. A few years later, he also became a conjoint professor at the School of Medical Sciences at the University of New South Wales. In 2008, Sinclair joined the scientific advisory board of Shaklee and helped them devise and introduce a product containing resveratrol called "Vivix"; after the Wall Street Journal requested an interview about his work with the company and its marketing, he disputed the use of his name and words to promote the supplement, and resigned. In 2011, Sinclair was a co-founder of OvaScience with Michelle Dipp (who had been involved with Sirtris), Aldrich, Westphal, and Jonathan Tilly, based on scientific work done by Tilly concerning mammalian oogonial stem cells and work on mitochondria by Sinclair. Tilly's work was controversial, with some groups unable to replicate it. The company came under pressure for skirting US regulatory authorities for fertility testing. In 2011, Sinclair was also a co-founder of CohBar, along with Nir Barzilai and other colleagues. CohBar aimed to discover and develop novel peptides derived from mitochondria. Cohbar describes itself as a clinical stage biotechnology company but has no drug candidates in clinical testing. In 2015, Sinclair described to The Scientist his efforts to get funding for his lab, how his lab grew to around 20 people, shrank back down to about 5, and then grew again as he brought in funding from philanthropic organizations and companies, including companies that he helped to start. In 2015, his lab had 22 people and was supported by one R01 grant and was 75% funded by non-federal funds. However, as of 2016, this was no longer true as his federal funding began to increase. In September 2019, Sinclair published Lifespan: Why We Age – and Why We Don't Have To, a New York Times bestseller, co-written with journalist Matthew LaPlante and translated into 18 languages. This was also released as an audiobook on Audible and read by Sinclair. Sinclair broadly discusses his longevity practices on social media and includes them in his book. They include daily doses of nicotinamide mononucleotide (NMN) and resveratrol, which Sinclair claims are activators of SIRT1. In November 2022, Sinclair's company Metro Biotech successfully urged the FDA to take actions to take NMN off the market as a supplement because Metro Biotech had registered NMN in investigational new drug applications. In 2023, Sinclair co-founded Tally Health, a supplement company with a stated goal is to "change the way we age" at a cellular level. Sinclair claims that improving his nutrition and exercise routine has shaved almost a decade off his biological age. In 2024, Sinclair and his brother Nicholas Sinclair announced that their company Animal Biosciences had proven that a supplement for dogs with nondisclosed ingredients reversed aging. This claim met with widely expressed outrage in the research community. The controversy resulted in a wave of resignations from The Academy for Health and Lifespan Research, a group of scientists that Sinclair had co-founded, and Sinclair resigned as the Academy's President in March 2024. Research Sinclair has expressed the view that there is no limit to human lifespan, and that there is a backup copy of the genetic and epigenetic information in us. While Sinclair was in Guarente's lab, he discovered that sirtuin 1 (called sir2 in yeast) slows aging in yeast by reducing the accumulation of extrachromosomal rDNA circles. Others working in the lab at the time identified NAD as an essential cofactor for sirtuin function. In 2002, after he had left for Harvard, he clashed with Guarente at a scientific meeting at Cold Spring Harbor Laboratory, challenging Guarante's description of how sir2 might be involved in aging; this set off a scientific rivalry. In 2003, Sinclair learned that scientists at a Pennsylvania biotech company called Biomol Research Laboratories had developed a biochemical assays in which they thought that polyphenols including resveratrol activated SIR2. This led to publications authored in part by Sinclair in both Nature an.... Discover the David A Sinclair Matthew D Laplante popular books. Find the top 100 most popular David A Sinclair Matthew D Laplante books.