J D Hollyfield Popular Books
J D Hollyfield Biography & Facts
Drusen, from the German word for node or geode (singular, "Druse"), are tiny yellow or white accumulations of extracellular material that build up between Bruch's membrane and the retinal pigment epithelium of the eye. The presence of a few small ("hard") drusen is normal with advancing age, and most people over 40 have some hard drusen. However, the presence of larger and more numerous drusen in the macula is a common early sign of age-related macular degeneration (AMD). Classification Drusen associated with aging and macular degeneration are distinct from another clinical entity, optic disc drusen, which is present on the optic nerve head. Both age-related drusen and optic disc drusen can be observed by ophthalmoscopy. Optical coherence tomography scans of the orbits or head, calcification at the head of the optic nerve without change in size of globe strongly suggests drusen in a middle-age or elderly patient. Whether drusen promote AMD or are symptomatic of an underlying process that causes both drusen and AMD is not known, but they are indicators of increased risk of the complications of AMD. 'Hard drusen' may coalesce into 'soft drusen' which is a manifestation of macular degeneration. Pathophysiology Around 1850, three authors, Carl Wedl, Franciscus Donders, and Heinrich Müller, gave drusen different labels. Drusen, the hallmark of AMD, were first described in 1854 by Wedl. Wedl named them colloid bodies of the choroid and thought that they were incompletely developed cells. Franciscus Donders called them "Colloidkugeln" (colloid spheres). Later, Heinrich Müller named them by the German word for geode, based on their glittering appearance. He was convinced that drusen originated from the nuclei of the pigment cells, which he believed to belong to the choroid. In view of their location between the retinal pigment epithelium (RPE) and its vascular supply, the choriocapillaris, it is possible that drusen deprive the RPE and photoreceptor cells of oxygen and nutrients. In some cases, drusen develop above the so-called pillars of the choriocapillaris that is the area between two micro vessels; although important variations are observed between different subtypes of AMD. The source of the proteins and lipids in drusen is also not clear, with potential contributions by both the RPE and the choroid. Several trace elements are present in drusen, probably the most concentrated being zinc. The protein composition of drusen includes apolipoproteins and oxidized proteins, likely originating from blood, RPE, and photoreceptors. Drusen composition also includes members of the complement system. Zinc in drusen has been suggested to play a role in drusen formation by precipitating and inhibiting the elements of the complement cascade, especially complement factor H. The presence of molecules that regulate inflammation in drusen has led some investigators to conclude that these deposits are product of the immune system. Diagnosis Usually being asymptomatic, drusen are typically found during routine eye exams where the pupils have been dilated. Treatment Laser treatment of drusen has been studied. While it is possible to eliminate drusen with this treatment strategy, it has been shown that this fails to reduce the risk of developing the choroidal neovascularisation which causes the blindness associated with age-related macular degeneration. See also Optic disc drusen Notes Mishra S, Goel S, Roy SS, Garg B, Parvin M, Saurabh K, Roy R. Multimodal imaging characteristics of refractile drusen. Indian journal of ophthalmology. 2019 Jan;67(1):128. . Discover the J D Hollyfield popular books. Find the top 100 most popular J D Hollyfield books.
Best Seller J D Hollyfield Books of 2024
-
Life in a Rut, Love not Included
J.D. HollyfieldHaving it all isn’t all it’s cracked up to be. When Sarah Sullivan’s perfect life blows up in front of her, she finds herself crawling back to the one place she never saw herself r...
-
Life Next Door
J.D. HollyfieldThere is only one thing in life that professional pastry Chef Priscilla Westcott values more than baking and wine, and that’s honesty. A quality she soon learns that her marriage l...
-
Hate 2 Lovers
J.D. Hollyfield & K. WebsterThis is book two in the series. It is best if you read book one first to fully understand this couple's story.She hates him and his big head.He likes her and her big tts.She hates ...
-
Chicks, Man
J.D. HollyfieldFalling in love was the easy part. Being secretly in love with my brother’s best friend is where it got tricky. Levi Dent was offlimits. Which was probably for the best, since he ...
-
Lake Redstone
J.D. HollyfieldCasey doesn't have much luck in the dating department, so when her girlfriends ditch their girls only weekend for a couple's retreat, she's forced to take desperate measures.Refusi...
-
My So Called Life
J.D. HollyfieldLife couldn’t be any brighter for art dealer Christina Daniels. At the top of her career, she has no problem flaunting just how perfect her little world has become.When tragedy str...
-
Faking It
J.D. HollyfieldFake it till you make it.That’s Lexi Hall, the wild socialite’s motto for how to live life.Single and allergic to commitment, Lexi is having the time of her life. Or is she? With a...
-
Worth the Chase
J.D. HollyfieldFrom USA Today bestselling author J.D. Hollyfield comes a heartwarming, laughoutloud romantic comedy about falling in love with your onenight stand. But of course, it can’t be that...
-
Thieves 2 Lovers
J.D. Hollyfield & K. WebsterBest friends aren’t supposed to kiss.But these best friends did.He can’t get the taste of her lips off his mind.She can’t let go of the guilt from her mistake.He wants to be good e...
-
Conheartists
J.D. Hollyfield & K. WebsterSheltered from the real world, Francis lives off Hollywood magazines, Lean Cuisines, and her secret obsession with romance novels. When her best friends set her up on an adventure ...
-
Text 2 Lovers
J.D. Hollyfield & K. WebsterIt’s the start of nothing good.I fired off a storm of raunchy text messages…to the wrong number.And he replied.Him: Show me a picture.Him: Tell me your name.Why does the lure of an...
-
Life as we Know It
J.D. HollyfieldLife has not been easy for Penelope Summers. Specifically, the last month, when her highprofile boyfriend dumped her, her indecent exposure record surfaced, and her favorite thing ...
-
Enemies with Benefits
J.D. HollyfieldBen Love? Yeah, hard pass. It has the power to take everything from youeven yourself. It’s why I stay clear. Don’t get me wrong. I’m a big fan of instalust. The kind that only l...