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The citric acid cycle (CAC)—also known as the Krebs cycle or the TCA cycle (tricarboxylic acid cycle)—is a series of chemical reactions to release stored energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins. The Krebs cycle is used by organisms that respire (as opposed to organisms that ferment) to generate energy, either by anaerobic respiration or aerobic respiration. In addition, the cycle provides precursors of certain amino acids, as well as the reducing agent NADH, that are used in numerous other reactions. Its central importance to many biochemical pathways suggests that it was one of the earliest components of metabolism and may have originated abiogenically. Even though it is branded as a 'cycle', it is not necessary for metabolites to follow only one specific route; at least three alternative segments of the citric acid cycle have been recognized.The name of this metabolic pathway is derived from the citric acid (a tricarboxylic acid, often called citrate, as the ionized form predominates at biological pH) that is consumed and then regenerated by this sequence of reactions to complete the cycle. The cycle consumes acetate (in the form of acetyl-CoA) and water, reduces NAD+ to NADH, releasing carbon dioxide. The NADH generated by the citric acid cycle is fed into the oxidative phosphorylation (electron transport) pathway. The net result of these two closely linked pathways is the oxidation of nutrients to produce usable chemical energy in the form of ATP. In eukaryotic cells, the citric acid cycle occurs in the matrix of the mitochondrion. In prokaryotic cells, such as bacteria, which lack mitochondria, the citric acid cycle reaction sequence is performed in the cytosol with the proton gradient for ATP production being across the cell's surface (plasma membrane) rather than the inner membrane of the mitochondrion. The overall yield of energy-containing compounds from the citric acid cycle is three NADH, one FADH2, and one GTP. Discovery Several of the components and reactions of the citric acid cycle were established in the 1930s by the research of Albert Szent-Györgyi, who received the Nobel Prize in Physiology or Medicine in 1937 specifically for his discoveries pertaining to fumaric acid, a key component of the cycle. He made this discovery by studying pigeon breast muscle. Because this tissue maintains its oxidative capacity well after breaking down in the Latapie mill and releasing in aqueous solutions, breast muscle of the pigeon was very well qualified for the study of oxidative reactions. The citric acid cycle itself was finally identified in 1937 by Hans Adolf Krebs and William Arthur Johnson while at the University of Sheffield, for which the former received the Nobel Prize for Physiology or Medicine in 1953, and for whom the cycle is sometimes named the "Krebs cycle". Overview The citric acid cycle is a key metabolic pathway that connects carbohydrate, fat, and protein metabolism. The reactions of the cycle are carried out by eight enzymes that completely oxidize acetate (a two carbon molecule), in the form of acetyl-CoA, into two molecules each of carbon dioxide and water. Through catabolism of sugars, fats, and proteins, the two-carbon organic product acetyl-CoA is produced which enters the citric acid cycle. The reactions of the cycle also convert three equivalents of nicotinamide adenine dinucleotide (NAD+) into three equivalents of reduced NAD+ (NADH), one equivalent of flavin adenine dinucleotide (FAD) into one equivalent of FADH2, and one equivalent each of guanosine diphosphate (GDP) and inorganic phosphate (Pi) into one equivalent of guanosine triphosphate (GTP). The NADH and FADH2 generated by the citric acid cycle are, in turn, used by the oxidative phosphorylation pathway to generate energy-rich ATP. One of the primary sources of acetyl-CoA is from the breakdown of sugars by glycolysis which yield pyruvate that in turn is decarboxylated by the pyruvate dehydrogenase complex generating acetyl-CoA according to the following reaction scheme: The product of this reaction, acetyl-CoA, is the starting point for the citric acid cycle. Acetyl-CoA may also be obtained from the oxidation of fatty acids. Below is a schematic outline of the cycle: The citric acid cycle begins with the transfer of a two-carbon acetyl group from acetyl-CoA to the four-carbon acceptor compound (oxaloacetate) to form a six-carbon compound (citrate). The citrate then goes through a series of chemical transformations, losing two carboxyl groups as CO2. The carbons lost as CO2 originate from what was oxaloacetate, not directly from acetyl-CoA. The carbons donated by acetyl-CoA become part of the oxaloacetate carbon backbone after the first turn of the citric acid cycle. Loss of the acetyl-CoA-donated carbons as CO2 requires several turns of the citric acid cycle. However, because of the role of the citric acid cycle in anabolism, they might not be lost, since many citric acid cycle intermediates are also used as precursors for the biosynthesis of other molecules. Most of the electrons made available by the oxidative steps of the cycle are transferred to NAD+, forming NADH. For each acetyl group that enters the citric acid cycle, three molecules of NADH are produced. The citric acid cycle includes a series of oxidation reduction reaction in mitochondria. In addition, electrons from the succinate oxidation step are transferred first to the FAD cofactor of succinate dehydrogenase, reducing it to FADH2, and eventually to ubiquinone (Q) in the mitochondrial membrane, reducing it to ubiquinol (QH2) which is a substrate of the electron transfer chain at the level of Complex III. For every NADH and FADH2 that are produced in the citric acid cycle, 2.5 and 1.5 ATP molecules are generated in oxidative phosphorylation, respectively. At the end of each cycle, the four-carbon oxaloacetate has been regenerated, and the cycle continues.Steps There are ten basic steps in the citric acid cycle, as outlined below. The cycle is continuously supplied with new carbon in the form of acetyl-CoA, entering at step 0 in the table. Two carbon atoms are oxidized to CO2, the energy from these reactions is transferred to other metabolic processes through GTP (or ATP), and as electrons in NADH and QH2. The NADH generated in the citric acid cycle may later be oxidized (donate its electrons) to drive ATP synthesis in a type of process called oxidative phosphorylation. FADH2 is covalently attached to succinate dehydrogenase, an enzyme which functions both in the CAC and the mitochondrial electron transport chain in oxidative phosphorylation. FADH2, therefore, facilitates transfer of electrons to coenzyme Q, which is the final electron acceptor of the reaction catalyzed by the succinate:ubiquinone oxidoreductase complex, also acting as an intermediate in the electron transport chain.Mitochondria in animals, including humans, possess two succinyl-CoA synthet.... Discover the Jbc Empower Press popular books. Find the top 100 most popular Jbc Empower Press books.

Best Seller Jbc Empower Press Books of February 2023

The Art of Logical Thinking e-book Download

The Art of Logical Thinking

William Walker AtkinsonFebruary 28, 2013Get

Atkinson talks about successful pedagogical approach, guiding through the fundamental elements of formal deductive logic, classification and definition, fallacies, basic argument analysis, i...

Explicit Instruction e-book Download

Explicit Instruction

Scarlett FinnJune 24, 2014Get

Enemies to lovers: Held captive by a dirty-talking alpha. "I wouldn't do that if I were you." Lost, Flick walks into a nightmare. More terrifying than the evil that captured her, a looming s...

I Have a Secret e-book Download

I Have a Secret

Cheryl BradshawApril 25, 2012Get

"The ending is a complete surprise!" - Reader  Doug Ward has been running from his past for twenty years. But after his fourth whisky of the night, his steely resolve has started to cra...

Law of Attraction e-book Download

Law of Attraction

Jordan HollisAugust 29, 2018Get

How to Finally Overcome the Hurdles of Manifesting Proven, effective and enjoyable ways to help you manifest faster… Right now, think of something that makes you successful. If you have so...

Fighter's Frenemy e-book Download

Fighter's Frenemy

A. RiversMarch 31, 2022Get

I've craved his love for years, but I was invisible to him. Now that I'm ready to move on, he suddenly sees me. And he won't let me go. As the shy, plus-size twin sister of a professional ca...

Catch e-book Download

Catch

Evelyn MontogmeryJanuary 4, 2022Get

Hunter  One look. One touch. One sound of her beautiful voice, and I’m hooked. Like a dream I never want to wake up from, she pulls me in and wraps me around her. Consumed. Driven wit...

How to Find Peace e-book Download

How to Find Peace

Beau NortonSeptember 23, 2015Get

Shatter the Illusions and Discover the Truth To 'know about' something is very different from KNOWING it. Perhaps you have some spiritual knowledge, but how often do you experience ...

The Art of War e-book Download

The Art of War

Sun TzuOctober 4, 2010Get

An Apple Books Classic edition. It’s believed that Sun Tzu wrote this Chinese military primer during the 5th century BC-hundreds of years before the Bible. The book’s 13 chapters explore...

The Devil I Don't Know: An Arranged Marriage Mafia Romance e-book Download

The Devil I Don't Know: An Arranged Marriage Mafia Romance

L.K. ShawMay 25, 2021Get

Jacob My father is dying, and I’ve been called back to Brooklyn to take my place as the head of the Italian syndicate. After a seven year absence, my first test of loyalty is to marry the ...

Emotional Intelligence Mastery: A Practical Guide to Improving Your EQ e-book Download

Emotional Intelligence Mastery: A Practical Guide to Improving Your EQ

Eric JordanAugust 2, 2016Get

Become Emotionally Smarter with a Practical Approach! Emotional intelligence has been a buzzword in the personal growth industry and in high-level corporate recruitment strategies since 1995...

The Wonderful Wizard of Oz e-book Download

The Wonderful Wizard of Oz

L. Frank BaumMay 17, 1900Get

An Apple Books Classic edition. You’ve seen the iconic 1939 movie, but do you know about the talking field mice, the Winkies, and the Witch of the North that appear in the original book? L...

Watch Me e-book Download

Watch Me

Stacey KennedySeptember 15, 2020Get

In the Phoenix club, there is only one rule; watch, don't touch, until the powerful owner falls for his new star in this deliciously intriguing romance from USA Today bestselling author Stac...

The Complete Works of Edgar Allan Poe (Illustrated, Inline Footnotes) e-book Download

The Complete Works of Edgar Allan Poe (Illustrated, Inline Footnotes)

Edgar Allan PoeSeptember 16, 2016Get

The Novels of Edgar Allan Poe. • Narrative Of A. Gordon Pym. (Inline Footnotes) • The Journal Of Julius Rodman. (Illustrated / Inline Footnotes) The Complete Tales of Edgar Allan Poe. (I...

The Science of Getting Rich e-book Download

The Science of Getting Rich

Wallace D. WattlesJuly 8, 2013Get

The Secret to Wealth and Prosperity is Closer Than You Think, It's Right Inside You. Follow Wallace D. Wattles as he helps you to make a startling discovery that you hold all the keys to you...

Brant e-book Download

Brant

Jodi BasyeFebruary 14, 2022Get

He's a cranky cowboy trying to save the family ranch. She's a freelance journalist hoping to get a full-time writing gig. What she writes could either make or break him. Brant Cross feels re...

Mistletoe Madness: A Sweet Small Town Christmas Romance (Santa's Secret Helpers, Book 2) e-book Download

Mistletoe Madness: A Sweet Small Town Christmas Romance (Santa's Secret Helpers, Book 2)

Leeanna MorganApril 21, 2020Get

Fans of Robyn Carr's Virgin River series will love this small-town, feel-good romance! This Christmas, something magical is happening in Sapphire Bay. Kylie loves everything about Christmas....

The Missing Ones e-book Download

The Missing Ones

Patricia GibneyMarch 16, 2017Get

The hole they dug was not deep. A white flour bag encased the little body. Three small faces watched from the window, eyes black with terror.   The child in the middle spoke without tur...

iPhone User Guide e-book Download

iPhone User Guide

Apple Inc.September 12, 2022Get

Here’s everything you need to know about iPhone, straight from Apple. This definitive guide helps you get started using iPhone with iOS 16 and discover all the amazing things it can do.

Moby Dick e-book Download

Moby Dick

Herman MelvilleOctober 17, 1851Get

An Apple Books Classic edition. Herman Melville’s classic begins with one of the most famous opening lines in world literature: “Call me Ishmael.” Moby Dick was a commercial failure wh...

Seascapes and Vegas Mistakes e-book Download

Seascapes and Vegas Mistakes

Kay LyonsApril 18, 2022Get

When a Las Vegas prank turns into an accidental and very legal marriage, Isabel Shipley is dead set on getting a discreet and hasty divorce. The last thing the struggling artist wants is to ...

Seduction Island e-book Download

Seduction Island

Autumn GazeNovember 30, 2022Get

You cannot escape the reality of tomorrow by evading it today… Ethan Mitchell flees New York to Oahu to escape a family scandal. He doesn't want to be a part of it. He ends up meeting Ava ...

Pride and Prejudice e-book Download

Pride and Prejudice

Jane AustenJanuary 28, 1813Get

An Apple Books Classic edition. Jane Austen’s beloved classic opens with this witty and very memorable line: “It is a truth universally acknowledged, that a single man in possession of a...

Bedtime Stories for Kids e-book Download

Bedtime Stories for Kids

Uncle AmonJune 15, 2015Get

Are you looking for a children's book that is highly entertaining, great for early readers, and is jam-packed with bedtime stories? This children's storybook has it all! This is an excellent...

What I Like About You e-book Download

What I Like About You

Kait NolanJuly 19, 2019Get

A horse-whispering loner After years as an Army Ranger, Sebastian Donnelly is content to be left alone with his horses. He's better with them than with...people. But that changes when his bo...

The Hunted e-book Download

The Hunted

A.J. ScudiereJune 20, 2019Get

Lights out. Keep still. Pray for morning. Joule and Cage Mazur feel like prisoners in their home. With something new stalking the streets at night, their family’s only protection is boltin...

Severance e-book Download

Severance

AnonymousMarch 18, 2022Get

When does the cost of staying silent become greater than the price of speaking up? A desperate woman risks everything to expose the sinister company at the heart of Severance , the thrilling...

Complicate Me: Reid & Sienna #1 e-book Download

Complicate Me: Reid & Sienna #1

Claire RayeJuly 8, 2020Get

Complicate Me is book one of Reid and Sienna’s duet and book one in the Hawthorn Hills Duet Series. A two-part, angst-filled, slow-burn, epic love story. Complicate Me must be read before ...

Already Gone (A Laura Frost FBI Suspense Thriller—Book 1) e-book Download

Already Gone (A Laura Frost FBI Suspense Thriller—Book 1)

Blake PierceMay 11, 2021Get

Haunted by visions of the future, FBI Special Agent Laura Frost must tap her psychic talent to hunt diabolical serial killers—while keeping it secret from everyone around her. But with a t...

Mr. Mayfair e-book Download

Mr. Mayfair

Louise BayOctober 1, 2019Get

My boyfriend is getting married. Okay, technically he's my ex-boyfriend. Two months ago he decided he wanted a break. I still thought he was my happily ever after. On any other day, knowing ...

Kingdoms of Sand: Books 1-3 e-book Download

Kingdoms of Sand: Books 1-3

Daniel ArensonOctober 23, 2018Get

Game of Thrones  meets  Spartacus  in an epic saga of sand and splendor. This bundle contains the first three novels of  Kingdoms of Sand , a fantasy series from a  ...

Undone (A Cora Shields Suspense Thriller—Book 1) e-book Download

Undone (A Cora Shields Suspense Thriller—Book 1)

Blake PierceOctober 11, 2022Get

In this action-packed mystery thriller by #1 bestselling author Blake Pierce, Cora Shields, 30, former Navy Seal turned FBI Special Agent, will stop at nothing to catch a killer— but she i...

Fighter's Heart e-book Download

Fighter's Heart

A. Rivers & Alexa RiversJanuary 20, 2022Get

He's tattooed, cocky, and hot as hell. The MMA superstar everyone loves to hate. Now it's my job to clean up his image…before it's too late. I never meant to become the P.R. specialist for...

iPad User Guide e-book Download

iPad User Guide

Apple Inc.October 24, 2022Get

Here’s everything you need to know about iPad, straight from Apple. This definitive guide helps you get started using iPad with iPadOS 16 and discover all the amazing things it can do.

10-Minute Social Psychology e-book Download

10-Minute Social Psychology

Albert RutherfordJune 7, 2020Get

Would you like to instantly catch people's thoughts, emotions, motivations, and intentions through mere observation? If yes, you've come to the right place!  10-Minute So...

Lady Danger e-book Download

Lady Danger

Glynnis CampbellOctober 12, 2014Get

Over 250,000 copies read worldwide! The Warrior Maids of Rivenloch... Damsels in shining armor...riding to the rescue! Deirdre, Helena, and Miriel, three kick-arse Scots wenches known as The...

Alice's Adventures in Wonderland e-book Download

Alice's Adventures in Wonderland

Lewis CarrollNovember 25, 1865Get

An Apple Books Classic edition. Fall down the proverbial rabbit hole with Alice, the intrepid heroine of Lewis Carroll’s classic fantasy! When Alice spies a talking rabbit, she can’t res...

Shiftless e-book Download

Shiftless

Aimee EasterlingOctober 24, 2014Get

Terra is shiftless --- a werewolf uncomfortable in her own animal skin. A decade after learning to squash her wolf and flee the repressive village where she grew up, the packless ache still ...

The Chase e-book Download

The Chase

Elle KennedyAugust 6, 2018Get

New York Times bestseller! The first book in a new series from international bestselling author Elle Kennedy!  Everyone says opposites attract. And they must be right, because there’s...

Cruel Captor e-book Download

Cruel Captor

Kaye BlueDecember 17, 2021Get

I’ve become the mafia’s most feared enforcer for a single purpose. Revenge. Now I have it my grasp, and she’s the key. Take her. Use her. Discard her. Why do I care that she’s innoce...

Manifesting Abundance: How to Manifest Your Desires Using the Law of Attraction e-book Download

Manifesting Abundance: How to Manifest Your Desires Using the Law of Attraction

Beau NortonSeptember 26, 2015Get

Did you know that up to 95% of the people that attempt to use the law of attraction to manifest their desires see no noticeable results? The truth is that most people fail to use the law of ...

Fighter's Best Friend e-book Download

Fighter's Best Friend

A. Rivers & Alexa RiversJanuary 20, 2022Get

My best friend is hot, rich, and emotionally unavailable. Falling in love with him is the worst idea ever but try telling that to my heart. As a doctor who aced her way through medical schoo...

Mindfulness for Beginners: A Practical Guide To Awakening and Finding Peace In Your Life! e-book Download

Mindfulness for Beginners: A Practical Guide To Awakening and Finding Peace In Your Life!

Alexander YamashitaJune 19, 2016Get

This book contains proven steps and strategies on how to apply the concepts and practices of mindfulness in day to day life.This textual guide begins by presenting common scenarios and moder...

Wuthering Heights e-book Download

Wuthering Heights

Emily BrontëNovember 30, 1847Get

An Apple Books Classic edition. If you’ve only ever seen Wuthering Heights on screen, you may have an image of Catherine and Heathcliff as the ultimate star-crossed lovers. But that’s ju...

Hunting Season e-book Download

Hunting Season

Kate RudolphApril 5, 2021Get

This werewolf will protect his mate. Owen has one job: keep Stasia from being abducted. Easier said than done when his fiercely independent client tries to fire him the moment they meet. His...

Stop Procrastinating & Overthinking: Learn The Mind Hacks To Cure Your Procrastination Habit And Improve Your Perseverance To Overcome Laziness. Eliminate Negative Thoughts And Stop Worrying e-book Download

Stop Procrastinating & Overthinking: Learn The Mind Hacks To Cure Your Procrastination Habit And Improve Your Perseverance To Overcome Laziness. Eliminate Negative Thoughts And Stop Worrying

Sebastian GoodwinMarch 25, 2021Get

"I TRIED EVERYTHING ELSE, BUT IT'S STILL A NEVER-ENDING BATTLE…" Everybody knows that procrastination is the biggest waste of time – I am talking about those moments when you imagine wha...

Fat Cat Finds a Home e-book Download

Fat Cat Finds a Home

Michelle SmithFebruary 20, 2015Get

After ten years of love from her previous owner, poor Fat Cat finds herself alone and looking for a new home. Will she ever leave the adoption shelter? Even at ten years old, Fat Cat still h...

The Very Hungry Caterpillar Library Books 1.1 e-book Download

The Very Hungry Caterpillar Library Books 1.1

Eric CarleMay 24, 2017Get

This is the series of The Very Hungry Caterpillar Little Learning Library Books. This book with Audio has been created as a university project for my last year. I have created lyrics and mus...

Nowhere Safe (A Harley Cole FBI Suspense Thriller—Book 1) e-book Download

Nowhere Safe (A Harley Cole FBI Suspense Thriller—Book 1)

Kate BoldSeptember 1, 2022Get

“This is an excellent book… When you start reading, be sure you don’t have to wake up early!” —Reader review for The Killing Game FBI BAU special agent Harley Cole, as brilliant as...

Holy Bible e-book Download

Holy Bible

The Church of Jesus Christ of Latter-day SaintsMarch 1, 2013Get

The 2013 edition of the Holy Bible contains all of the study aids contained in the 1979 edition and includes revisions to the study aids, several new photos, updated maps, and adjustments to...

Little Women e-book Download

Little Women

Louisa May AlcottSeptember 29, 1868Get

An Apple Books Classic edition. Meet the Marches! Louisa May Alcott’s classic introduces us to four unforgettable sisters: beautiful Meg, tomboyish Jo, delicate Beth, and Amy, the indulged...

Best Seller Jbc Empower Press Audio Books of February 2023

The Mountain is You: Transforming Self-Sabotage Into Self-Mastery audiobook
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Manifest audiobook
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Never Finished: Unshackle Your Mind and Win the War Within (Unabridged) audiobook
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Atlas of the Heart: Mapping Meaningful Connection and the Language of Human Experience (Unabridged) audiobook
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Harry Potter and the Half-Blood Prince audiobook
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Attached: The New Science of Adult Attachment and How It Can Help You Find--and Keep-- Love (Unabridged) audiobook
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