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White blood cells, also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders. All white blood cells are produced and derived from multipotent cells in the bone marrow known as hematopoietic stem cells. Leukocytes are found throughout the body, including the blood and lymphatic system.All white blood cells have nuclei, which distinguishes them from the other blood cells, the anucleated red blood cells (RBCs) and platelets. The different white blood cells are usually classified by cell lineage (myeloid cells or lymphoid cells). White blood cells are part of the body's immune system. They help the body fight infection and other diseases. Types of white blood cells are granulocytes (neutrophils, eosinophils, and basophils), and agranulocytes (monocytes, and lymphocytes (T cells and B cells)).Myeloid cells (myelocytes) include neutrophils, eosinophils, mast cells, basophils, and monocytes. Monocytes are further subdivided into dendritic cells and macrophages. Monocytes and neutrophils are phagocytic. Lymphoid cells (lymphocytes) include T cells (subdivided into helper T cells, memory T cells, cytotoxic T cells), B cells (subdivided into plasma cells and memory B cells), and natural killer cells. Historically, white blood cells were classified by their physical characteristics (granulocytes and agranulocytes), but this classification system is less frequently used now. Produced in the bone marrow, they defend your body against infections and disease. But, when there are too many white blood cells, it usually means you have infection or inflammation in your body. Less commonly, a high white blood cell count could indicate certain blood cancers or bone marrow disorders. The number of leukocytes in the blood is often an indicator of disease, and thus the white blood cell count is an important subset of the complete blood count. The normal white cell count is usually between 4 × 109/L and 1.1 × 1010/L. In the US, this is usually expressed as 4,000 to 11,000 white blood cells per microliter of blood. White blood cells make up approximately 1% of the total blood volume in a healthy adult, making them substantially less numerous than the red blood cells at 40% to 45%. However, this 1% of the blood makes a large difference to health, because immunity depends on it. An increase in the number of leukocytes over the upper limits is called leukocytosis. It is normal when it is part of healthy immune responses, which happen frequently. It is occasionally abnormal, when it is neoplastic or autoimmune in origin. A decrease below the lower limit is called leukopenia. This indicates a weakened immune system. Etymology The name "white blood cell" derives from the physical appearance of a blood sample after centrifugation. White cells are found in the buffy coat, a thin, typically white layer of nucleated cells between the sedimented red blood cells and the blood plasma. The scientific term leukocyte directly reflects its description. It is derived from the Greek roots leuk- meaning "white" and cyt- meaning "cell". The buffy coat may sometimes be green if there are large amounts of neutrophils in the sample, due to the heme-containing enzyme myeloperoxidase that they produce. Types Overview All white blood cells are nucleated, which distinguishes them from the anucleated red blood cells and platelets. Types of leukocytes can be classified in standard ways. Two pairs of broadest categories classify them either by structure (granulocytes or agranulocytes) or by cell lineage (myeloid cells or lymphoid cells). These broadest categories can be further divided into the five main types: neutrophils, eosinophils, basophils, lymphocytes, and monocytes. These types are distinguished by their physical and functional characteristics. Monocytes and neutrophils are phagocytic. Further subtypes can be classified. Granulocytes are distinguished from agranulocytes by their nucleus shape (lobed versus round, that is, polymorphonuclear versus mononuclear) and by their cytoplasm granules (present or absent, or more precisely, visible on light microscopy or not thus visible). The other dichotomy is by lineage: Myeloid cells (neutrophils, monocytes, eosinophils and basophils) are distinguished from lymphoid cells (lymphocytes) by hematopoietic lineage (cellular differentiation lineage). Lymphocytes can be further classified as T cells, B cells, and natural killer cells. Neutrophil Neutrophils are the most abundant white blood cell, constituting 60-70% of the circulating leukocytes. They defend against bacterial or fungal infection. They are usually first responders to microbial infection; their activity and death in large numbers form pus. They are commonly referred to as polymorphonuclear (PMN) leukocytes, although, in the technical sense, PMN refers to all granulocytes. They have a multi-lobed nucleus, which consists of three to five lobes connected by slender strands. This gives the neutrophils the appearance of having multiple nuclei, hence the name polymorphonuclear leukocyte. The cytoplasm may look transparent because of fine granules that are pale lilac when stained. Neutrophils are active in phagocytosing bacteria and are present in large amount in the pus of wounds. These cells are not able to renew their lysosomes (used in digesting microbes) and die after having phagocytosed a few pathogens. Neutrophils are the most common cell type seen in the early stages of acute inflammation. The average lifespan of inactivated human neutrophils in the circulation has been reported by different approaches to be between 5 and 135 hours. Eosinophil Eosinophils compose about 2-4% of white blood cells in circulating blood. This count fluctuates throughout the day, seasonally, and during menstruation. It rises in response to allergies, parasitic infections, collagen diseases, and disease of the spleen and central nervous system. They are rare in the blood, but numerous in the mucous membranes of the respiratory, digestive, and lower urinary tracts.They primarily deal with parasitic infections. Eosinophils are also the predominant inflammatory cells in allergic reactions. The most important causes of eosinophilia include allergies such as asthma, hay fever, and hives; and parasitic infections. They secrete chemicals that destroy large parasites, such as hookworms and tapeworms, that are too big for any one white blood cell to phagocytize. In general, their nuclei are bi-lobed. The lobes are connected by a thin strand. The cytoplasm is full of granules that assume a characteristic pink-orange color with eosin staining. Basophil Basophils are chiefly responsible for allergic and antigen response by releasing the chemical histamine causing the dilation of blood vessels. Because they are the rarest of the white blood cells (less than 0.5% of the total count) and share physicochemical properties with oth.... Discover the Violet Marrow popular books. Find the top 100 most popular Violet Marrow books.

Best Seller Violet Marrow Books of December 2022

An Acquired Taste e-book Download

An Acquired Taste

Kelly CainJune 8, 2021Get

May the best chef win... After four years at the country’s top culinary school and several years as head chef in her mother’s restaurant, Rowan Townsend has built a notable reputation. H...

Manifesting Abundance: How to Manifest Your Desires Using the Law of Attraction e-book Download

Manifesting Abundance: How to Manifest Your Desires Using the Law of Attraction

Beau NortonSeptember 26, 2015Get

Did you know that up to 95% of the people that attempt to use the law of attraction to manifest their desires see no noticeable results? The truth is that most people fail to use the law of ...

Become A Better Version of Yourself e-book Download

Become A Better Version of Yourself

Ben LeightonFebruary 22, 2015Get

This ebook contains golden nuggets on how to motivate, inspire and improve your current situation. It encompasses the holistic view of self improvement from mental& emotional wellbeing, ...

The Crash e-book Download

The Crash

Skye WarrenJune 14, 2022Get

Carter Morelli works alone, but his orders are clear. Pilot the small aircraft carrying the renowned photographer to a remote island. June Porter wants to stay on solid land. She doesn't...

Wanna Puck? (Book Two) e-book Download

Wanna Puck? (Book Two)

Layla Valentine & Ana SparksDecember 24, 2021Get

One cool-as-ice veteran player One smoking hot rising star And little old me in the middle All wrapped up in an all-star ménage a trois I've been sent to write a piece on two NHL stars Joel...

The Bangover e-book Download

The Bangover

Lili ValenteOctober 3, 2019Get

Note to Self --Do NOT bang your best guy friend in the limo on the way to the swanky Vegas hotel. I give myself very good advice. Too bad I suck at taking it. If only Colin and I hadn't ...

The Killing Game (An Alexa Chase Suspense Thriller—Book 1) e-book Download

The Killing Game (An Alexa Chase Suspense Thriller—Book 1)

Kate BoldOctober 15, 2021Get

Alexa Chase, 34, a brilliant profiler in the FBI’s Behavioral Analysis Unit, was too good at her job. Haunted by all the serial killers she caught, she left a stunning career behind to joi...

Small Town Big Rumors e-book Download

Small Town Big Rumors

Willow WintersFebruary 8, 2022Get

He tasted like tequila and the fake name I gave him was Rose. Four years ago, I decided to get over one man, by getting under another. A single night and nothing more. I found my handsome st...

Man In The Water e-book Download

Man In The Water

Jon HillOctober 5, 2021Get

An attempted murder. A missing spouse. And an international conspiracy that could change the world. Jack Green has always been skeptical of so-called facts. Though he's forced to confront th...

Bare Ass in Love e-book Download

Bare Ass in Love

Sasha BurkeAugust 26, 2017Get

The woman's killing me. I'm not the kind of man who would normally even consider blurring the lines between landlord and tenant or boss and employee, but Summer is a walking temptation. Neur...

Falling for Prince Charming: A Feel-Good Romantic Comedy e-book Download

Falling for Prince Charming: A Feel-Good Romantic Comedy

Sophie-Leigh RobbinsSeptember 7, 2021Get

Falling for your best friend's brother is tricky… unless you're keeping it a secret. Elle I never thought I'd be serving hotdogs dressed as an actual hotdog at the local amusement park. No...

The Baltic Run e-book Download

The Baltic Run

Charles WhitingJune 15, 2020Get

From the carnage of war a new hero is born. 1920. The slaughter of World War One is over, but already secret little wars are breaking out all over 'New Europe'. Sub-Lieutenant de Vere Smith ...

Lost Souls e-book Download

Lost Souls

W.J. MayNovember 22, 2018Get

Your curse is your biggest strength. I just didn't know it yet. Jamie Hunt's the high school quarterback in his senior year. He's popular, smart, got the prettiest girl in the school chasing...

Falling for a Rake e-book Download

Falling for a Rake

Eve PendleNovember 29, 2021Get

He's the most notorious rake in England. She's a Perfect Lady. Their secrets will come tumbling out. . . A sexy opposites attract fake engagement romance! Lady Emily can't afford a scandal. ...

Liberty Begins e-book Download

Liberty Begins

Leigh JamesFebruary 13, 2015Get

Adventure. Fate. From Rags to Riches… My name is Liberty and I'm a good girl. I come from nothing. I have no one but myself. Sometimes I do things I don't want to -- I do them beca...

The Wonderful Wizard of Oz e-book Download

The Wonderful Wizard of Oz

L. Frank BaumMay 17, 1900Get

An Apple Books Classic edition. You’ve seen the iconic 1939 movie, but do you know about the talking field mice, the Winkies, and the Witch of the North that appear in the original book? L...

Just One Night e-book Download

Just One Night

Carly PhillipsApril 20, 2021Get

She’s the woman he can’t live without. The one he can’t risk screwing up their relationship by sleeping with her. Linc Kingston doesn’t accept anything less than perfection. ...

The Girl Outside: A Shocking and Gripping Psychological Thriller e-book Download

The Girl Outside: A Shocking and Gripping Psychological Thriller

James CaineJune 22, 2022Get

Her daughter has a dark secret. One that will turn their perfect small town upside down.  Now she's missing. Mandy Knox can't shake the gut wrenching feeling that something sinister hap...

Smitten with Ravioli e-book Download

Smitten with Ravioli

Ellen JacobsonMay 22, 2020Get

I'm not sure what I'm more scared of—cats that drool or falling for that annoying history professor in my Italian cooking course. Sure, Preston Whitaker has amazing blue eyes, but he's an ...

10-Minute Social Psychology e-book Download

10-Minute Social Psychology

Albert RutherfordJune 7, 2020Get

Would you like to instantly catch people's thoughts, emotions, motivations, and intentions through mere observation? If yes, you've come to the right place!  10-Minute So...

Moby Dick e-book Download

Moby Dick

Herman MelvilleOctober 17, 1851Get

An Apple Books Classic edition. Herman Melville’s classic begins with one of the most famous opening lines in world literature: “Call me Ishmael.” Moby Dick was a commercial failure wh...

Take a Chance on Me e-book Download

Take a Chance on Me

Kathryn R. BielMay 21, 2020Get

She's finally getting her life back together. His is falling apart. It's the perfect time to take a chance. Nobody likes packing up their things and moving to a small town in the middle of n...

Persuasion e-book Download

Persuasion

Jane AustenJune 16, 2020Get

Persuasion was published in 1817, six months after Jane Austen’s death, and is the last novel she completed in full. The novel tells the story of Anne Elliot, now in her late 20s, the daug...

Savage Prince e-book Download

Savage Prince

Meghan MarchApril 24, 2018Get

Who knew things could get even darker and dirtier in New Orleans?  New York Times  bestselling author Meghan March introduces the  Savage Prince  of the city, the man you...

Secrets and Scandals e-book Download

Secrets and Scandals

Piper GlendaleMay 5, 2022Get

Emily Delaney, a reporter for one of Hollywood’s hottest gossip magazines, has her world turned upside down when her former journalism mentor dies, and she is called back to the hometown s...

The Sheep Who Couldn't Sleep e-book Download

The Sheep Who Couldn't Sleep

Simon JamieAugust 1, 2012Get

One night down on Hillside Farm Everything was quiet and calm But all alone there lay a sheep Who found he couldn't get to sleep. Follow Sheep as he tries to find the best way to get to slee...

Come Back for Me e-book Download

Come Back for Me

Corinne MichaelsJanuary 7, 2020Get

From  New York Times  Bestselling author Corinne Michaels comes a new emotional and riveting standalone love story. One night, eight years ago, she gave me peace. No names. No prom...

Little Women e-book Download

Little Women

Louisa May AlcottSeptember 29, 1868Get

An Apple Books Classic edition. Meet the Marches! Louisa May Alcott’s classic introduces us to four unforgettable sisters: beautiful Meg, tomboyish Jo, delicate Beth, and Amy, the indulged...

Right Time e-book Download

Right Time

Lexy TimmsFebruary 11, 2022Get

Don't rush on anything.  If the time is right, it will happen. Rae I've always known I was meant to get out of the dead-end side of town where I was born. Trevor is my plan. He's from t...

Pride and Prejudice e-book Download

Pride and Prejudice

Jane AustenJanuary 28, 1813Get

An Apple Books Classic edition. Jane Austen’s beloved classic opens with this witty and very memorable line: “It is a truth universally acknowledged, that a single man in possession of a...

Mr. Trouble e-book Download

Mr. Trouble

Nana MaloneAugust 1, 2018Get

Yeah, I'm trouble...so what? Women like it. That and my big...bank account. Not to mention my, ah, silver tongue. I'm the prince of my world, right up until the king gets upset. My f...

The Chase e-book Download

The Chase

Elle KennedyAugust 6, 2018Get

New York Times bestseller! Get ready for another binge-worthy romance from international bestselling author Elle Kennedy! Everyone says opposites attract. And they must be right, because the...

Coming Home to Glendale Hall e-book Download

Coming Home to Glendale Hall

Victoria WaltersSeptember 25, 2019Get

'WOW! From the first page I was absolutely hooked ...Would highly recommend to get you in a feel good mood!’ (5 stars) Netgalley reviewer Uplifting and full of heart - this is an utter tre...

Accidentally Aphrodite e-book Download

Accidentally Aphrodite

Dakota CassidySeptember 24, 2019Get

An apple a day keeps the Goddess in play... Mythology buff Quinn Morris has always wanted to visit Greece, where her inner hardcore romantic envisioned proposing to her boyfriend. And she's ...

Explicit Erotic Sex Short Stories e-book Download

Explicit Erotic Sex Short Stories

Brenda BlanchardJanuary 5, 2021Get

Bestselling Erotica Author Brenda Blanchard Is Giving Away a Collection of Some of Her Best Work! "Explicit Erotic Sex Short Stories" by Brenda Blanchard gives you a sneak peek into the sedu...

Bred By The Boss #1: Alyssa e-book Download

Bred By The Boss #1: Alyssa

Arwen RichJuly 3, 2018Get

Alyssa is untouched by any man – until her hot, demanding boss Mr. Ramirez comes into her life. Her fantasy comes true when he has his way with her, rough and unprotected. But as a result,...

Abigail's Shop e-book Download

Abigail's Shop

Rachael HerronOctober 22, 2021Get

“I didn’t just  imply  that you weren’t welcome. I’m making sure you know that’s the case.” Don’t miss the incredible first standalone in this unputdownable series th...

Love in a Small Town e-book Download

Love in a Small Town

Zoe YorkOctober 6, 2020Get

Are they one late-night hayride away from tumbling back into a very bad idea? Olivia Minelli needs a one-way ticket out of Pine Harbour. It's too small for both her and her ex-husband. So wh...

Bedtime Stories for Kids e-book Download

Bedtime Stories for Kids

Uncle AmonJune 15, 2015Get

Are you looking for a children's book that is highly entertaining, great for early readers, and is jam-packed with bedtime stories? This children's storybook has it all! This is an excellent...

Scraps of Paper e-book Download

Scraps of Paper

Kathryn Meyer GriffithSeptember 13, 2014Get

Abigail Sutton's beloved husband walks out one night, doesn't return, and two years later is found dead, a victim of a long ago crime. It's made her sympathetic to the missing and their fami...

Girl, Alone (An Ella Dark FBI Suspense Thriller—Book 1) e-book Download

Girl, Alone (An Ella Dark FBI Suspense Thriller—Book 1)

Blake PierceDecember 16, 2020Get

FBI Agent Ella Dark has studied serial killers from the time she could read, devastated by the murder of her own sister. With her photographic memory, she has obtained an encyclopedic knowle...

Persuasion e-book Download

Persuasion

Jane AustenDecember 31, 1817Get

A woman of no importance, she manoeuvres in her restricted circumstances as her long-time love Captain Wentworth did in the wars. Even though she is nearly thirty, well past the sell-by bloo...

Star Bright e-book Download

Star Bright

Susannah NixApril 19, 2022Get

She’s an A-list Hollywood starlet. He’s a gossip reporter. Sleeping with the enemy has never been sweeter…  Kimberleigh Cress didn’t get to be one of the one of the hottest youn...

Romancing His Rival e-book Download

Romancing His Rival

Poppy St JamesAugust 16, 2021Get

Two enemies. One wedding. The plan was simple . . . until they started to fall for each other.  Noah and Olivia are total opposites. She’s buttoned up and proper, focused en...

Don't Play With Odin e-book Download

Don't Play With Odin

Cynthia EdenJuly 13, 2021Get

Big, bad, and currently out of his element... Odin Shaw thought he’d spend his life on a battlefield. But fate had other plans, and now the former Special Forces operative has just landed ...

Maneuver e-book Download

Maneuver

Chelle BlissJuly 31, 2018Get

This isn’t how fairy tales typically begin, but it’s where mine starts… No money, no phone, and abandoned on the streets of Chicago. With my baby in my arms, I wander into a bar in a s...

Man Crush Monday e-book Download

Man Crush Monday

Kirsty MoseleyFebruary 3, 2020Get

Perma-single Amy Clarke prides herself on three things: her pink hair, her Converse collection, and her ability to drink copious amounts of margarita without puking. She isn’t looking for ...

The Tanglewood Tea Shop e-book Download

The Tanglewood Tea Shop

Lilac MillsJanuary 31, 2019Get

What happens after your dreams come true? Patisserie-Chef Stevie is stuck in a rut. Her beloved Great Aunt Peggy has passed away and she’s lost both her job and the love of her life. Then ...

Someone Else's Daughter e-book Download

Someone Else's Daughter

Linsey LanierOctober 29, 2010Get

Book I of the popular Miranda's Rights Mystery series by bestselling author Linsey Lanier.  A woman can never make herself too tough, too strong, or too street smart.  THE SEARCHIN...

Contract with a SEAL e-book Download

Contract with a SEAL

Kate AsterSeptember 7, 2016Get

Some contracts are meant to be broken... Desperate to shake herself free from the humiliation of a very public divorce, TV financial correspondent Vi Owens makes a deal with a Navy SEAL Comm...

Best Seller Violet Marrow Audio Books of December 2022

True Believer (Unabridged) audiobook
True Believer (Unabridged)Jack Carr$16.99

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The Body Keeps the Score: Brain, Mind, and Body in the Healing of Trauma (Unabridged) audiobook
The Body Keeps the Score: Brain, Mind, and Body in the Healing of Trauma (Unabridged)Bessel van der Kolk, M.D.$14.99

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The Fellowship of the Ring audiobook
The Fellowship of the RingJ.R.R. Tolkien$19.99

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The Power Of Positive Thinking (Unabridged) audiobook
The Power Of Positive Thinking (Unabridged)Dr. Norman Vincent Peale$19.99

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Unfu*k Yourself audiobook
Unfu*k YourselfGary John Bishop$12.99

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The Secret (Unabridged) audiobook
The Secret (Unabridged)Rhonda Byrne$12.99

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Finding Me audiobook
Finding MeViola Davis$19.99

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The Devil's Hand (Unabridged) audiobook
The Devil's Hand (Unabridged)Jack Carr$14.99

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Kitchen Confidential: Adventures in the Culinary Underbelly (Unabridged) audiobook
Kitchen Confidential: Adventures in the Culinary Underbelly (Unabridged)Anthony Bourdain$12.99

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Think and Grow Rich audiobook
Think and Grow RichNapoleon Hill$14.99

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In the Blood (Unabridged) audiobook
In the Blood (Unabridged)Jack Carr$14.99

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Endure audiobook
EndureCameron Hanes$16.99

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Harry Potter and the Order of the Phoenix audiobook
Harry Potter and the Order of the PhoenixJ.K. Rowling$39.99

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Harry Potter and the Prisoner of Azkaban audiobook
Harry Potter and the Prisoner of AzkabanJ.K. Rowling$25.99

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The It Girl (Unabridged) audiobook
The It Girl (Unabridged)Ruth Ware$14.99

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Reminders of Him: A Novel (Unabridged) audiobook
Reminders of Him: A Novel (Unabridged)Colleen Hoover$25.99

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Savage Son (Unabridged) audiobook
Savage Son (Unabridged)Jack Carr$14.99

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The Hobbit audiobook
The HobbitJ.R.R. Tolkien$14.99

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They Want to Kill Americans audiobook
They Want to Kill AmericansMalcolm Nance$19.99

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Breath: The New Science of a Lost Art (Unabridged) audiobook
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Extreme Ownership audiobook
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We'll Always Have Summer audiobook
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The Richest Man in Babylon audiobook
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It Happened One Summer audiobook
It Happened One SummerTessa Bailey$14.99

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Atlas of the Heart: Mapping Meaningful Connection and the Language of Human Experience (Unabridged) audiobook
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Good to Great audiobook
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A Court of Thorns and Roses audiobook
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The Seven Husbands of Evelyn Hugo (Unabridged) audiobook
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The Midnight Library: A Novel (Unabridged) audiobook
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