Metastasis of Prostate Cancer Book Reviews
Metastasis of Prostate Cancer by Richard J. Ablin & Malcolm D. Mason Book Summary
Without metastasis, prostate cancer would be both tolerable and treatable. The high incidence of indolent and organ confined disease is testament to this sweeping generalisation. Equally, if molecular markers of metastatic spread can be identified, then the choice of treatment for many patients would be easier and more radical, even curative. However, should prevention and treatment of the primary tumors prove difficult or impossible, then a knowledge of the phenotype of advanced metastatic tumors should allow us to target these lesions for destruction by conventional (drug based) or more innovative means such as gene and/or immunotherapy (1). The process of metastasis has been reviewed many times (e. g. , 2) and has been subdivided for ease of analysis into a number of discrete stages (see Figure 1). It has been suggested that at least 10 separate genetic 2. ECM degradation: migration MMP ; Integrin ; TIMP 3. Intravasation MMP TIMP 1. Cellular independence 4. Transport Adhesion loss and evasion (E Cadherin ) of host immune system MHCClass1 ICAM-1 to block T cell receptor 5. Arrest of movement: endothelial adhesion CD44 or switch 6. Extravasation to colonise new site 7. Proliferation at Laminin R distant site to form Integrin switch METASTASIS Figure 1. Stages in prostate cancer metastasis. Basic processes in tumor metastases are indicated in the boxes with some key changes in gene expression indicated at each stage by the solid arrows.
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| Book Name | Metastasis of Prostate Cancer |
| Genre | Medical |
| Author | Richard J. Ablin & Malcolm D. Mason |
| Published | 05 September 2007, Wednesday |
| Language | English |
| E-Book Size | 5.84 MB |
Metastasis of Prostate Cancer (Richard J. Ablin & Malcolm D. Mason) Book Reviews 2024
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| Download Link | Book Format |
| metastasis-of-prostate-cancer-ebook.pdf | |
| metastasis-of-prostate-cancer-ebook.epub | EPUB |
| metastasis-of-prostate-cancer-ebook.kindle | KINDLE |
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Summary of Metastasis of Prostate Cancer by Richard J. Ablin & Malcolm D. Mason
The Metastasis of Prostate Cancer book written by Richard J. Ablin & Malcolm D. Mason was published on 05 September 2007, Wednesday in the Medical category. A total of 164 readers of the book gave the book 0 points out of 5.
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