Ar Taboo Popular Books
Ar Taboo Biography & Facts
Androgen insensitivity syndrome (AIS) is a condition involving the inability to respond to androgens, typically due to androgen receptor dysfunction. It affects 1 in 20,000 to 64,000 XY (karyotypically male) births. The condition results in the partial or complete inability of cells to respond to androgens. This unresponsiveness can impair or prevent the development of male genitals, as well as impairing or preventing the development of male secondary sexual characteristics at puberty. It does not significantly impair female genital or sexual development. The insensitivity to androgens is therefore clinically significant only when it occurs in genetic males, (i.e. individuals with a Y-chromosome, or more specifically, an SRY gene). Clinical phenotypes in these individuals range from a typical male habitus with mild spermatogenic defect or reduced secondary terminal hair, to a full female habitus, despite the presence of a Y-chromosome. AIS is divided into three categories that are differentiated by the degree of genital masculinization: Mild androgen insensitivity syndrome (MAIS) is indicated when the external genitalia are those of a typical male (a penis and a scrotum) Partial androgen insensitivity syndrome (PAIS) is indicated when the external genitalia are partially, but not fully, masculinized Complete androgen insensitivity syndrome (CAIS) is indicated when the external genitalia are those of a typical female (a vulva) Androgen insensitivity syndrome is the largest single entity that leads to 46,XY undermasculinized genitalia. Management of AIS is currently limited to symptomatic management; no method is currently available to correct the malfunctioning androgen receptor proteins produced by AR gene mutations. Areas of management include sex assignment, genitoplasty, gonadectomy to reduce tumor risk, hormone replacement therapy, genetic counseling, and psychological counseling. Genetics The human androgen receptor (AR) is a protein encoded by a gene located on the proximal long arm of the X chromosome (locus Xq11-Xq12). The protein coding region consists of approximately 2,757 nucleotides (919 codons) spanning eight exons, designated 1-8 or A-H. Introns vary in size between 0.7 and 26 kb. Like other nuclear receptors, the AR protein consists of several functional domains: the transactivation domain (also called the transcription-regulation domain or the amino / NH2-terminal domain), the DNA-binding domain, the hinge region, and the steroid-binding domain (also called the carboxyl-terminal ligand-binding domain). The transactivation domain is encoded by exon 1, and makes up more than half of the AR protein. Exons 2 and 3 encode the DNA-binding domain, while the 5' portion of exon 4 encodes the hinge region. The remainder of exons 4 through 8 encodes the ligand binding domain. Trinucleotide satellite lengths and AR transcriptional activity The AR gene contains two polymorphic trinucleotide microsatellites in exon 1. The first microsatellite (nearest the 5' end) contains 8 to 60 repetitions of the glutamine codon "CAG" and is thus known as the polyglutamine tract. The second microsatellite contains 4 to 31 repetitions of the glycine codon "GGC" and is known as the polyglycine tract. The average number of repetitions varies by ethnicity, with Caucasians exhibiting an average of 21 CAG repeats, and Blacks 18. In men, disease states are associated with extremes in polyglutamine tract length; prostate cancer, hepatocellular carcinoma, and intellectual disability are associated with too few repetitions, while spinal and bulbar muscular atrophy (SBMA) is associated with a CAG repetition length of 40 or more. Some studies indicate that the length of the polyglutamine tract is inversely correlated with transcriptional activity in the AR protein, and that longer polyglutamine tracts may be associated with male infertility and undermasculinized genitalia in men. However, other studies have indicated no such correlation exists. A comprehensive meta-analysis of the subject published in 2007 supports the existence of the correlation, and concluded these discrepancies could be resolved when sample size and study design are taken into account. Some studies suggest longer polyglycine tract lengths are also associated with genital masculinization defects in men. Other studies find no such association. AR mutations As of 2010, over 400 AR mutations have been reported in the AR mutation database, and the number continues to grow. Inheritance is typically maternal and follows an X-linked recessive pattern; individuals with a 46,XY karyotype always express the mutant gene since they have only one X chromosome, whereas 46,XX carriers are minimally affected. About 30% of the time, the AR mutation is a spontaneous result, and is not inherited. Such de novo mutations are the result of a germ cell mutation or germ cell mosaicism in the gonads of one of the parents, or a mutation in the fertilized egg itself. In one study, three of eight de novo mutations occurred in the postzygotic stage, leading to the estimate that up to one-third of de novo mutations result in somatic mosaicism. Not every mutation of the AR gene results in androgen insensitivity; one particular mutation occurs in 8 to 14% of genetic males, and is thought to adversely affect only a small number of individuals when other genetic factors are present. Other causes Some individuals with CAIS or PAIS do not have any AR mutations despite clinical, hormonal, and histological features sufficient to warrant an AIS diagnosis; up to 5% of women with CAIS do not have an AR mutation, as well as between 27 and 72% of individuals with PAIS. In one patient, the underlying cause for presumptive PAIS was a mutant steroidogenic factor-1 (SF-1) protein. In another patient, CAIS was the result of a deficit in the transmission of a transactivating signal from the N-terminal region of the androgen receptor to the basal transcription machinery of the cell. A coactivator protein interacting with the activation function 1 (AF-1) transactivation domain of the androgen receptor may have been deficient in this patient. The signal disruption could not be corrected by supplementation with any coactivators known at the time, nor was the absent coactivator protein characterized, which left some in the field unconvinced that a mutant coactivator would explain the mechanism of androgen resistance in CAIS or PAIS patients with a typical AR gene. XY karyotype Depending on the mutation, a person with a 46,XY karyotype and AIS can have either a male (MAIS) or female (CAIS) phenotype, or may have genitalia that are only partially masculinized (PAIS). The gonads are testes regardless of phenotype due to the influence of the Y chromosome. A 46,XY female, thus, does not have ovaries, and can not contribute an egg towards conception. In some cases, 46, XY females do form a vestigial uterus and have been able to gestate childre.... Discover the Ar Taboo popular books. Find the top 100 most popular Ar Taboo books.
Best Seller Ar Taboo Books of 2024
-
Dark Psychology and Manipulation
Margaret MorrisonTHE MENTAL MANIPULATOR WILL NO LONGER KEEP SECRETS FROM YOU! Are you fed up with the wool being pulled over your eyes?Are you prepared to stand up to those who believe they can man...
-
Silver Hunter
Lacey SilksThey call her a cougar, but he calls her, his Queen. Grace Brooks, Manhattan's most soughtafter hair stylist, never expected Hunter, the young handyman with a knack for fixing...
-
Brush With Death
Mia HallMy first year at the Dreadmore Academy. What can go wrong? How long do you have? The list of stuff that can go right is much, much shorter.  I'm probably going to fai...
-
Bedtime Stories
Uncle AmonBedtime Stories: 5 Magical Adventures for Little Dreamers Embark on a whimsical journey to dreamland with "Bedtime Stories: Magical Adventures for Little Dreamers". This ...
-
Beautiful Darkness
Autumn GazeYou can have anything you want in life... You just can't have everything you want... Gareth is Fae. Sort of. His mother was a Nymph, and with that cross, he finds himself to b...
-
Mischief after Midnight
Jennifer BernardBartender Toni Del Rey is the quickwitted queen of the Olde Salt Saloon, famous for trading barbs with grizzled fishermen and putting rowdy customers in their place. Independent an...
-
The Great Gatsby
F. Scott FitzgeraldAn Apple Books Classics edition. The Roaring Twenties are in full effect in F. Scott Fitzgerald’s riveting classic. Manabouttown Jay Gatsby seems to have it all, including loads of...
-
Last Resort
Jill SandersWhen Cassey's business is in jeopardy, she gets an interesting offer from a local hotel owner. He has been trying to run her business into the ground so his family can snat...
-
The Scarlet Letter
Nathaniel HawthorneAn Apple Books Classic edition. Hester Prynne lives in infamy. After committing adultery and bearing a child with a man whose name she refuses to divulge, the heroine of Nathaniel ...
-
Heartbreaker
Melody GraceDiscover the steamy smalltown romance now a USA Today bestseller! Perfect for fans of Elsie Silver and Lucy Score. They say that time heals a broken heart, but you try moving on w...
-
The Wedding Bet
Susan HatlerA fun and uplifting story that will make you swoon and smile as two best friends fall in love. Kennedy needs to slow down, which is why her last boyfriend broke up with her. No mat...
-
Become A Better Version of Yourself
Ben LeightonThis ebook contains golden nuggets on how to motivate, inspire and improve your current situation. It encompasses the holistic view of self improvement from mental& emotion...
-
The Adventures of Sherlock Holmes
Arthur Conan DoyleAn Apple Books Classic You get not one, not two, but 25 gripping mysteries in Arthur Conan Doyle’s first of five collections of Sherlock Holmes short stories. Follow the brilliant ...
-
Silent Scream
Angela MarsonsFive figures gather round a shallow grave. They had all taken turns to dig. An adult sized hole would have taken longer. An innocent life had been taken but the pact had been made....
-
The Cottage on Nantucket
Jessie NewtonAfter their mother dies, two sisters return to the cottage where they spent their summers growing up. Nantucket Point is exactly the same: charming, warm, and filled with memories ...
-
Little Women
Louisa May AlcottAn Apple Books Classic edition. Meet the Marches! Louisa May Alcott’s classic introduces us to four unforgettable sisters: beautiful Meg, tomboyish Jo, delicate Beth, and Amy, the ...
-
Ice Crown
Kay L MoodyThe competition could save her life... But only if she wins. Talise can manipulate the elements with ease. Water, air, earth, and fire all bend to her will. As a citizen of the Sto...
-
The Wonderful Wizard of Oz
L. Frank BaumAn Apple Books Classic edition. You’ve seen the iconic 1939 movie, but do you know about the talking field mice, the Winkies, and the Witch of the North that appear in the original...
-
Collided
Portia MooreAlex I want Madison the moment I lay eyes on her. But I’ve got my work cut out for me because someone before me broke her heart and destroyed her trust. She's my friend, that&...
-
Holy Bible
The Church of Jesus Christ of Latter-day SaintsThe 2013 edition of the Holy Bible contains all of the study aids contained in the 1979 edition and includes revisions to the study aids, several new photos, updated maps, and adju...
-
Dream Psychology
Sigmund FreudAn Apple Books Classic edition. Written by the founding father of psychoanalysis, Sigmund Freud’s 1899 book is the definitive text on learning to interpret dreams. Freud’s groundbr...
-
A Light in the Window
Marion KummerowMargarete stumbles out of the bombedout house, the dust settling around her like snow. Mistaking her for the dead officer’s daughter, a guard rushes over to gently ask her if she i...
-
Boy Toy
S. E. LundTate McNaughton. 24 years old. Gorgeous. An artist independenly wealthy and the heir to a huge fortune. He's way too hot for my own good and seems intent on doing eve...
-
Destined Magic
Ruby RaineI'm twentyeight, still single, no career, just inherited a mansion filled with magical secrets, three cats, plus a demon hellbent on killing kill me because supposedly, I'...
-
The Hookup Equation
Roxie NoirTeach me everything. My whole life, I’ve been a good girl. I follow rules like nobody’s business. I obey guidelines like I was born to it. Show me a line, and I’ll toe it. I’m even...
-
The Girls on Chalk Hill
Alison BelshamThey lie on the hillside, wearing matching white dresses, tiaras in their blonde hair. Each of them clutches a red rose. They could be sleeping, but frost shines on the lashes of t...
-
Knock Knock
Chris Merritt⭐⭐⭐⭐⭐ ‘ Wow. I absolutely loved this book!... I was not able to put it down from the moment I started it, so much so that I devoured it in just two days .’ Goodreads reviewer Natas...
-
The Holy Bible - King James Version
King JamesHoly Bible King James Version Few Sample Paragraphs from The Holy Bible eBook, Genesis (OT) 1 Gen. 1 IN the beginning God created the heaven and the earth. 2 And the earth was with...
-
If I Break
Portia Moore~THIS BOOK IS BEST ENJOYED WHEN YOU DON'T READ ANY REVIEWS OR SPOILERS BEFORE READING. GOING IN BLIND IS HIGHLY RECOMMENDED. I PROMISE!~ Cal effin' Scott. Hell in a Arman...
-
Teach Me The Ropes
Vanessa ValeMeet the Manning brothers in this steamy small town cowboy series from USA Today Bestselling author Vanessa Vale! A bachelor auction. I was in a fing bachelor auction. I wasn'...
-
The Odyssey
HomerAn Apple Books Classic edition. Homer’s eighthcentury epic poem is a companion to The Iliad . It tells the story of Odysseus, who journeys by ship for 10 years after the Trojan War...
-
The Three Little Pigs
Mark LeskyClassic fairy tales, legends and folk stories in short version without violence retold with lovely illustrations in simple language. Perfect for reading aloud to small chi...
-
Her Texas Ex
Katherine GarberaShe couldn't forget him, even if she tried... When Amelia Corbyn was a vulnerable teen, she found out she wasn’t a Corbyn by blood. Her biological father was a legendary count...
-
No Room For Regret
Janeen Ann O'ConnellThe movement of the ship seals his fate. He could be sailing anywhere, anytime, but he's not, he's going to the other side of the world. He could be anyone, but he's...
-
Wormwood Abbey
Christina BaehrAs a Victorian clergyman's daughter, Edith Worms has seen everything until a mythical salamander tumbles out of the fireplace into her lap. When a letter arrives from estrang...
-
Spark of Passion
Lexy TimmsI wish my head could forget what my eyes have seen… Two years after running a black ops mission in Syria, Dane Morrison is struggling with PTSD while serving his Aspen community as...
-
Beautiful Storm
Barbara Freethy“ "Barbara Freethy’s Romantic Suspense books are explosively good!"  –New York Times bestselling author Toni Anderson. From #1 NY Times Bestsel...
-
Meditations
Marcus AureliusWritten in Greek by the only Roman emperor who was also a philosopher, without any intention of publication, the Meditations of Marcus Aurelius offer a remarkable series of challen...
-
Against the Boards
Cynthia GundersonPeople say opposites attract, but now I have proof. There's zero rationale for why I would fall for Tyler Bowen. I mean, he's the star winger of my brother's hockey ...
-
Opal
Freya BarkerWhen Opal goes undercover in a youth center several teenagers have disappeared from, she’s shocked to find a ghost of her own traumatic past at the helm. However, her worry for the...
-
Wrong Places
Teralyn MitchellSometimes the path to happily ever after runs through all the wrong places… Romance never did Maggie Anthony any favors. So now that she’s back in her small hometown as a divorced ...
-
Through the Looking-Glass
Lewis CarrollAn Apple Books Classics edition. Travel back to Wonderland in Lewis’s acclaimed sequel to Alice’s Adventures in Wonderland . When Alice’s game of “Let’s pretend” turns real, she fi...
-
Serendipity
Carly PhillipsHe’s from the wrong side of the tracks. She lived in the house on the hill. Now their fortunes have reversed…but their longago attraction still burns. From high school golden girl ...
-
Silenced Girls
Roger Stelljes“ Wow wow wow! Grips you in a choke hold and does not let go … Oozes suspense and bonechilling twists and turns . Astonishing … One of those rare books you stay up all night to rea...
-
Just One Time
Samantha BacaThere are worse things than turning forty.    However, I can't seem to evade my worry of my biological clock, and my fear that time is running out. I've...
-
Game Changer
Piper LawsonA steamy, grumpy sunshine sports romance featuring a woman down on her luck, a star basketball player with a filthy mouth, and a connection neither of them can deny. After being du...
-
Imperfect Chemistry
Mary FrameShe's never understood the point of romance, but now he's going to show her. Lucy London puts the word genius to shame. Having obtained her PhD in microbiology by the age...
-
Doubly Claimed
C.D. GorriWill this curvy redhead find her match with two smexy shifters? Needing a break from her nightmare boss, Ginger is more than ready for the Freeman sisters' annual vacation. Sh...
-
The Grumpy Dinosaur
Michael GordonEmotions & Feelings Series Book 2 A little Dinosaur gets annoyed easily, sometimes for no reason at all! Anger is a normal, healthy emotion. It's OK to feel a...
-
The Secret Diary of an Arranged Marriage
Halima KhatunWinner of the 2021 Bookbrunch Selfie Award for Best Adult I know I'll land a husband… but will he be the one? The Secret Diary of an Arranged Marriage – A Hilarious Romcom Tha...