John Joseph Defazio Jeanne C Defazio Popular Books
John Joseph Defazio Jeanne C Defazio Biography & Facts
Blepharospasm is a neurological disorder characterized by intermittent, involuntary spasms and contractions of the orbicularis oculi (eyelid) muscles around both eyes. These result in abnormal twitching or blinking, and in the extreme, sustained eyelid closure resulting in functional blindness. The word blepharospasm is derived from the Greek: βλέφαρον / blepharon, eyelid, and σπασμός / spasmos, spasm, an uncontrolled muscle contraction. The condition should be distinguished from the more common, and milder, involuntary quivering of an eyelid, known as myokymia or fasciculation. Blepharospasm is one form of a group of movement disorders called dystonia. It may be a primary or secondary disorder. The primary disorder is benign essential blepharospasm, in which term the qualifier essential indicates that the cause is unknown. Blepharospasm may occur as secondary to conditions including dry eyes and other specific ocular disease or conditions, Meige's Syndrome and other forms of dystonia, and Parkinson's Disease and other movement disorders. Blepharospasm occurs in middle age and is more frequent among women than men. The most common treatments are medication and periodic injections of botulinum toxin into the eyelid muscles. Epidemiology Blepharospasm is a fairly rare disease. Estimates of incidence and prevalence vary, tending to be higher in population studies than service studies, likely because of delays in diagnosis. In the United States, approximately 2,000 new cases of blepharospasm are diagnosed each year. Estimates of incidence per million persons-years range from 14.5 in Northern California to 100 in Taiwan. Estimates of prevalence per million range from 12 in Olmsted County, Minnesota to 133 in Puglia, Southern Italy. The onset of blepharospasm tends to be during the ages 40-60. The condition is roughly more than twice as frequent among females than males, which may be related to menopause and hormone treatments. In Taiwan, the condition is more frequent among white- than blue-collar workers. Signs and symptoms Blepharospasm usually begins with occasional twitches of both eyelids, which progress over time to forceful and frequent spasms and contractions of the eyelids. In severe episodes, the patient cannot open their eyelids (apraxia), which severely limits their daily activities. Prolonged closure of the eyelids may result in functional blindness. Patients suffering from blepharospasm also report sensory symptoms including sensitivity to light, dry eyes, and burning sensation and grittiness in the eyes. Although such symptoms tend to precede the onset of the blepharospasm, they may both be due to a common third factor. Typically, the symptoms---spasms and contractions of the eyelids---tend to worsen when the patient relaxes but abate during sleep. The symptoms may be temporarily alleviated by sensory tricks (geste antagoniste) including stretching or rubbing the eyebrows, eyelids, or forehead, and singing, talking, or humming. Blepharospasm is aggravated by fatigue, stress, and environmental factors such as wind or air pollution. Although blepharospasm is defined as a bilaterally symmetric disorder that affects both eyes, some research has reported unilateral onset. Causes Historically, it was believed that blepharospasm was due to the abnormal functioning of the brain's basal ganglia. The basal ganglia are structures in the brain that are involved in the regulation of motor and reward functions. However, blepharospasm is now known to involve several regions of the brain and to be a multifactorial condition in which "one or several as yet unknown genes together with epigenetic and environmental factors combine to reach the threshold that induces the disease". Blepharospasm is often associated with dry eyes, but the causal mechanism is still not clear. Research in New York and Italy suggests that increased blinking (which may be triggered by dry eyes) leads to blepharospasm. A case control study in China found that blepharospasm aggravated dry eyes. Blepharospasm may be associated with dystonia in other parts of the body, particularly Meige's Syndrome. Blepharospasm may be associated with Parkinson's Disease, but the causal mechanism is still not clear. In rare cases, blepharospasm is associated with multiple sclerosis. Some drugs can induce blepharospasm, including those used to treat depression and Parkinson's disease. Hormone replacement therapy for women going through menopause has been found to be associated with dry eyes, which in turn is associated with blepharospasm. Blepharospasm can be caused by concussions in some rare cases, when a blow to the back of the head damages the basal ganglia. Blepharospasm is associated with exposure to the sun. Diagnosis No laboratory tests exist with which to definitively diagnose blepharospasm. Historically, the condition was frequently misdiagnosed, often as a psychiatric condition. Diagnosis of blepharospasm has been enhanced by the proposal of objective diagnostic criteria that start from "stereotyped, bilateral and synchronous orbicularis oculi spasms" and proceed to the identification of a "sensory trick" or "increased blinking". The criteria have been validated across multiple ethnicities in multiple centers. Treatment Standard first line treatments of blepharospasm are conservative therapies, oral medication, and periodic injections of botulinum toxin. Particularly when associated with dry eyes, blepharospasm may be relieved with warm compresses, eye drops, and eye wipes. A Japanese study showed that warm compresses containing menthol were more effective in increasing tear film. Drugs used to treat blepharospasm are anticholinergics, benzodiazepines, baclofen, and tetrabenazine. The proportion of patients who benefited from anticholinergics ranged from 1 in 9 in Oregon to 1 in 5 in England. Besides failing to resolve the blepharospasm, some drugs present the risk of side effects. In Japan, use of etizolam and benzodiazepine was associated with the development of blepharospasm. A case report from Sri Lanka suggests treatment with Mosapride. The main first-line therapy is periodic injections of botulinum toxin type A to induce localized, partial paralysis of the eyelid muscles. Injections are generally administered at intervals of around 10 weeks, with variations based on patient response and usually give fairly quick relief from the muscle spasms. An English study reported that 118 (78%) of 151 patients experienced significant relief of symptoms for a mean duration of 9.2 weeks. However, in a minority of patients, the injections do not provide any symptomatic relief. Injections of botulinum toxin may diminish in effectiveness with prolonged use and require increased dosage. Injections of botulinum toxin increase the risk of visual complaints and ptosis (eyelid droop). Patients who do not respond well to medication or botulinum toxin injections are candidates for surgical therapy. .... Discover the John Joseph Defazio Jeanne C Defazio popular books. Find the top 100 most popular John Joseph Defazio Jeanne C Defazio books.
Best Seller John Joseph Defazio Jeanne C Defazio Books of 2024
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Dracula
Bram StokerAn Apple Books Classic edition. Few characters have seized readers’ imaginations quite like Count Dracula of Transylvania, the hero of Bram Stoker’s classic. The 1897 novel put vam...
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Through the Looking-Glass
Lewis CarrollAn Apple Books Classics edition. Travel back to Wonderland in Lewis’s acclaimed sequel to Alice’s Adventures in Wonderland . When Alice’s game of “Let’s pretend” turns real, she fi...
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The Good Knight
Sarah WoodburyDON'T MISS THE SALE ON THE NEXT BOOKS IN THE SERIES! When a king is murdered on the way to his wedding, Gareth & Gwen join forces in their first mystery together! Five...
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Boy Toy
S. E. LundTate McNaughton. 24 years old. Gorgeous. An artist independenly wealthy and the heir to a huge fortune. He's way too hot for my own good and seems intent on doing eve...
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Behind Closed Doors
Sherri HayesFalling For His New Neighbor Was Never Part of the Plan  Chris Daniels is single, and he prefers to keep it that way. Women are trouble. One look at his new neighbor has a...
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Protect Me
Margaret WatsonPolice officer Mia Donovan is studying for the detective's exam when her captain offers her an assignment – be Finn O'Rourke's personal bodyguard for the next three ...
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Become A Better Version of Yourself
Ben LeightonThis ebook contains golden nuggets on how to motivate, inspire and improve your current situation. It encompasses the holistic view of self improvement from mental& emotion...
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Against the Boards
Cynthia GundersonPeople say opposites attract, but now I have proof. There's zero rationale for why I would fall for Tyler Bowen. I mean, he's the star winger of my brother's hockey ...
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The Art of War
Sun TzuAn Apple Books Classic edition. It’s believed that Sun Tzu wrote this Chinese military primer during the 5th century BChundreds of years before the Bible. The book’s 13 chapters ex...
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Moby Dick
Herman MelvilleAn Apple Books Classic edition. Herman Melville’s classic begins with one of the most famous opening lines in world literature: “Call me Ishmael.” Moby Dick was a commercial failur...
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Brush With Death
Mia HallMy first year at the Dreadmore Academy. What can go wrong? How long do you have? The list of stuff that can go right is much, much shorter.  I'm probably going to fai...
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Silver Hunter
Lacey SilksThey call her a cougar, but he calls her, his Queen. Grace Brooks, Manhattan's most soughtafter hair stylist, never expected Hunter, the young handyman with a knack for fixing...
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Opal
Freya BarkerWhen Opal goes undercover in a youth center several teenagers have disappeared from, she’s shocked to find a ghost of her own traumatic past at the helm. However, her worry for the...
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10-Minute Social Psychology
Albert RutherfordWould you like to instantly catch people's thoughts, emotions, motivations, and intentions through mere observation? If yes, you've come to the...
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The Girls on Chalk Hill
Alison BelshamThey lie on the hillside, wearing matching white dresses, tiaras in their blonde hair. Each of them clutches a red rose. They could be sleeping, but frost shines on the lashes of t...
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Sunrise at Crystal Bay
Mia KentA decadelong secret. A devastating betrayal. And a chance to return to the placeand the boyshe left behind. Leah Turner had it alla happy marriage of twentyfive years, two grown ch...
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Anna Karenina
Leo TolstoyAn Apple Books Classic edition. “Happy families are all alike; every unhappy family is unhappy in its own way.” Thus begins what many consider the world’s greatest novel. Leo Tolst...
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Meditations
Marcus AureliusWritten in Greek by the only Roman emperor who was also a philosopher, without any intention of publication, the Meditations of Marcus Aurelius offer a remarkable series of challen...
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Doubly Claimed
C.D. GorriWill this curvy redhead find her match with two smexy shifters? Needing a break from her nightmare boss, Ginger is more than ready for the Freeman sisters' annual vacation. Sh...
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Holy Bible
The Church of Jesus Christ of Latter-day SaintsThe 2013 edition of the Holy Bible contains all of the study aids contained in the 1979 edition and includes revisions to the study aids, several new photos, updated maps, and adju...
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The Three Little Pigs
Mark LeskyClassic fairy tales, legends and folk stories in short version without violence retold with lovely illustrations in simple language. Perfect for reading aloud to small chi...
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Scorned Queen
Lisa Renee JonesThe protégé king wants the king unseated but it will be war, and a bloody one. And you can only push a future queen so far before she says enough, and proves she's as worthy f...
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Bedtime Stories
Uncle AmonBedtime Stories: 5 Magical Adventures for Little Dreamers Embark on a whimsical journey to dreamland with "Bedtime Stories: Magical Adventures for Little Dreamers". This ...
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Tongue Twisters for Kids
Riley Weber"Rubber baby buggy bumpers" Say this three times as fast as you can.  How about, try saying " Loopy lizards lying lazily aloft a little lane of logs,"...
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Ice Crown
Kay L MoodyThe competition could save her life... But only if she wins. Talise can manipulate the elements with ease. Water, air, earth, and fire all bend to her will. As a citizen of the Sto...
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Wrong Places
Teralyn MitchellSometimes the path to happily ever after runs through all the wrong places… Romance never did Maggie Anthony any favors. So now that she’s back in her small hometown as a divorced ...
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Finding Cinderella
Colleen Hoover#1 New York Times bestselling author of It Starts with Us and It Ends With Us writes a free novella about the search for happily ever after. A chance encounter in the dark leads ei...
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Make Me Forget
Anna BrooksOne lie can destroy everything... After enduring years of manipulation and an immeasurable amount of loss, Charlotte Kelly makes one last ditch effort to change her life and try to...
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A Tempest of Discovery
Sarah M. Cradit“Absolutely riveting!” "Cradit's delivery of mystery and intrigue is flawless." "Be still my heart. Nicolas Deschanel is back and better than ever." “A mus...
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Frankenstein
Mary ShelleyAn Apple Books Classic edition. Mary Shelley was just 18 when she had a nightmare vision: “I saw the pale student of unhallowed arts kneeling beside the thing he had put together. ...
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Winnie-the-Pooh
A.A. MilneAn Apple Books Classic edition. If you haven’t met Winnie the Pooh yet, stop reading this, and start reading the bookyou’ll be so glad you did. The jovial stuffed bear and his ragt...
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Silent Scream
Angela MarsonsFive figures gather round a shallow grave. They had all taken turns to dig. An adult sized hole would have taken longer. An innocent life had been taken but the pact had been made....
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If I Break
Portia Moore~THIS BOOK IS BEST ENJOYED WHEN YOU DON'T READ ANY REVIEWS OR SPOILERS BEFORE READING. GOING IN BLIND IS HIGHLY RECOMMENDED. I PROMISE!~ Cal effin' Scott. Hell in a Arman...
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The Cottage on Nantucket
Jessie NewtonAfter their mother dies, two sisters return to the cottage where they spent their summers growing up. Nantucket Point is exactly the same: charming, warm, and filled with memories ...
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Just One Time
Samantha BacaThere are worse things than turning forty.    However, I can't seem to evade my worry of my biological clock, and my fear that time is running out. I've...
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The Odyssey
HomerAn Apple Books Classic edition. Homer’s eighthcentury epic poem is a companion to The Iliad . It tells the story of Odysseus, who journeys by ship for 10 years after the Trojan War...
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Dream Psychology
Sigmund FreudAn Apple Books Classic edition. Written by the founding father of psychoanalysis, Sigmund Freud’s 1899 book is the definitive text on learning to interpret dreams. Freud’s groundbr...
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The Wonderful Wizard of Oz
L. Frank BaumAn Apple Books Classic edition. You’ve seen the iconic 1939 movie, but do you know about the talking field mice, the Winkies, and the Witch of the North that appear in the original...
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The Hookup Equation
Roxie NoirTeach me everything. My whole life, I’ve been a good girl. I follow rules like nobody’s business. I obey guidelines like I was born to it. Show me a line, and I’ll toe it. I’m even...
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No Room For Regret
Janeen Ann O'ConnellThe movement of the ship seals his fate. He could be sailing anywhere, anytime, but he's not, he's going to the other side of the world. He could be anyone, but he's...
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Beautiful Darkness
Autumn GazeYou can have anything you want in life... You just can't have everything you want... Gareth is Fae. Sort of. His mother was a Nymph, and with that cross, he finds himself to b...
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The Great Gatsby
F. Scott FitzgeraldAn Apple Books Classics edition. The Roaring Twenties are in full effect in F. Scott Fitzgerald’s riveting classic. Manabouttown Jay Gatsby seems to have it all, including loads of...
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Heartbreaker
Melody GraceDiscover the steamy smalltown romance now a USA Today bestseller! Perfect for fans of Elsie Silver and Lucy Score. They say that time heals a broken heart, but you try moving on w...
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Love Notes
Lexy TimmsWe're not here to take part, we're here to take over… I stood in the elevator, all my things in a cardboard box. Surrounding me, nearly every other employee clutched thei...
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Knock Knock
Chris Merritt⭐⭐⭐⭐⭐ ‘ Wow. I absolutely loved this book!... I was not able to put it down from the moment I started it, so much so that I devoured it in just two days .’ Goodreads reviewer Natas...
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The Duke Who Knew Too Much
Grace CallawayA #1 National Bestselling Regency Romance He's a rake accused of murder. She's the spinster accusing him. Enemies make the hottest lovers. "Readers looking for a goo...
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Beautiful Storm
Barbara Freethy“ "Barbara Freethy’s Romantic Suspense books are explosively good!"  –New York Times bestselling author Toni Anderson. From #1 NY Times Bestsel...
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The Power of Unlimited Faith
Kynan BridgesTake The Limits Off Your Faith! Do you ever hear people talk about “getting more faith” or “increasing their faith?”  When we buy into this idea, we never have enough. Tho...
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Close to the Ridge
Lexy TimmsClimb the mountain so you can see the world, not so the world can see you. In the end, all I learned was how to be strong. Alone. Lincoln is a former Navy Seal, hiding away in the ...
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Wuthering Heights
Emily BrontëAn Apple Books Classic edition. If you’ve only ever seen Wuthering Heights on screen, you may have an image of Catherine and Heathcliff as the ultimate starcrossed lovers. But that...