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St. Louis ( saynt LOO-iss, sənt-) is an independent city in the U.S. state of Missouri. It is located near the confluence of the Mississippi and the Missouri rivers. In 2020, the city proper had a population of 301,578, while its bi-state metropolitan area, which extends into Illinois, had an estimated population of over 2.8 million. It is the largest metropolitan area in Missouri and the second largest in Illinois. The city's combined statistical area (CSA) is the 20th largest in the United States. The land that is now St. Louis had been occupied by Native American cultures for thousands of years before European settlement. The city was founded on February 14, 1764, by French fur traders Gilbert Antoine de St. Maxent, Pierre Laclède and Auguste Chouteau. They named it for king Louis IX of France, and it quickly became the regional center of the French Illinois Country. In 1804, the United States acquired St. Louis as part of the Louisiana Purchase. In the 19th century, St. Louis developed as a major port on the Mississippi River; from 1870 until the 1920 census, it was the fourth-largest city in the country. It separated from St. Louis County in 1877, becoming an independent city and limiting its political boundaries. In 1904, it hosted the Louisiana Purchase Exposition, also known as the St. Louis World's Fair, and the Summer Olympics. St. Louis is designated as one of 173 global cities by the Globalization and World Cities Research Network. The GDP of Greater St. Louis was $209.9 billion in 2022. St. Louis has a diverse economy with strengths in the service, manufacturing, trade, transportation, and aviation industries. It is home to fifteen Fortune 1000 companies, seven of which are also Fortune 500 companies. Federal agencies headquartered in the city or with significant operations there include the Federal Reserve Bank of St. Louis, the U.S. Department of Agriculture, and the National Geospatial-Intelligence Agency. Major research universities in Greater St. Louis include Washington University in St. Louis, Saint Louis University, and the University of Missouri–St. Louis. The Washington University Medical Center in the Central West End neighborhood hosts an agglomeration of medical and pharmaceutical institutions, including Barnes-Jewish Hospital. St. Louis has four professional sports teams: the St. Louis Cardinals of Major League Baseball, the St. Louis Blues of the National Hockey League, St. Louis City SC of Major League Soccer, and the St. Louis BattleHawks of the United Football League. Among the city's notable attractions are the 630-foot (192 m) Gateway Arch in Downtown St. Louis, the St. Louis Zoo, the Missouri Botanical Garden, the St. Louis Art Museum, and Bellefontaine Cemetery and Arboretum. History Mississippian culture and European exploration The area that would become St. Louis was a center of the Native American Mississippian culture, which built numerous temple and residential earthwork mounds on both sides of the Mississippi River. Their major regional center was at Cahokia Mounds, active from 900 to 1500. Due to numerous major earthworks within St. Louis boundaries, the city was nicknamed as the "Mound City". These mounds were mostly demolished during the city's development. Historic Native American tribes in the area encountered by early Europeans included the Siouan-speaking Osage people, whose territory extended west, and the Illiniwek. European exploration of the area was first recorded in 1673, when French explorers Louis Jolliet and Jacques Marquette traveled through the Mississippi River valley. Five years later, La Salle claimed the region for France as part of La Louisiane, also known as Louisiana. The earliest European settlements in the Illinois Country (also known as Upper Louisiana) were built by the French during the 1690s and early 1700s at Cahokia, Kaskaskia, and Fort de Chartres. Migrants from the French villages on the east side of the Mississippi River, such as Kaskaskia, also founded Ste. Genevieve in the 1730s. In 1764, after France lost the Seven Years' War, Pierre Laclède and his stepson Auguste Chouteau founded what was to become the city of St. Louis. (French lands east of the Mississippi had been ceded to Great Britain and the lands west of the Mississippi to Spain; Catholic France and Spain were 18th-century allies. Louis XV of France and Charles III of Spain were cousins, both from the House of Bourbon.) The French families built the city's economy on the fur trade with the Osage, as well as with more distant tribes along the Missouri River. The Chouteau brothers gained a monopoly from Spain on the fur trade with Santa Fe. French colonists used African slaves as domestic servants and workers in the city. During the negotiations for the 1763 Treaty of Paris, French negotiators agreed to transfer France's colonial territories west of the Mississippi and Missouri rivers to New Spain to compensate for Spanish territorial losses during the war. These areas remained under Spanish control until 1803, when they were transferred to the French First Republic. During the American Revolutionary War, St. Louis was unsuccessfully attacked by British-allied Native Americans in the 1780 Battle of St. Louis. City founding The founding of St. Louis was preceded by a trading business between Gilbert Antoine de St. Maxent and Pierre Laclède (Liguest) in the fall of 1763. St. Maxent invested in a Mississippi River expedition led by Laclède, who searched for a location to base the company's fur trading operations. Though Ste. Genevieve was already established as a trading center, he sought a place less prone to flooding. He found an elevated area overlooking the flood plain of the Mississippi River, not far south from its confluence with the Missouri and Illinois rivers. In addition to having an advantageous natural drainage system, there were nearby forested areas to supply timber and grasslands which could easily be converted for agricultural purposes. This place, declared Laclède, "might become, hereafter, one of the finest cities in America." He dispatched his 14-year-old stepson, Auguste Chouteau, to the site, with the support of 30 settlers in February 1764. Laclède arrived at the future town site two months later and produced a plan for St. Louis based on the New Orleans street plan. The default block size was 240 by 300 feet, with just three long avenues running parallel to the west bank of the Mississippi. He established a public corridor of 300 feet fronting the river, but later this area was released for private development. For the first few years of St. Louis's existence, the city was not recognized by any of the governments. Although the settlement was thought to be under the control of the Spanish government, no one asserted any authority over it, and thus St. Louis had no local government. This vacuum led Laclède to assume civil control, and all problems were disposed in public settings, such as comm.... Discover the Missouri Court Of Appeals Kansas City Di popular books. Find the top 100 most popular Missouri Court Of Appeals Kansas City Di books.