Who is Bruce Spiegelman?

Bruce Spiegelman Popular Books

Bruce Spiegelman Biography & Facts

Bruce Michael Spiegelman is an American biochemist and cell biologist. Since 2008, Spiegelman has been the Stanley J. Korsmeyer Professor of Cell Biology and Medicine at the Dana–Farber Cancer Institute and Harvard Medical School, and Director of the Center for Metabolism and Chronic Disease at the Dana-Farber. Early life and education Spiegelman was raised in Massapequa, New York, US. He completed his Bachelor of Science degree from College of William & Mary and his PhD from Princeton University. During his time in Virginia, Spiegelman played on their NCAA Division I tennis team. Upon finishing his PhD in the laboratory of Marc Kirschner, Spiegelman conducted his postdoctoral training at Massachusetts Institute of Technology (MIT), in the laboratory of Howard Green, where he began working on fat cells. Career Following his postdoctoral training in 1982, Spiegelman joined the faculty at Harvard Medical School (HMS) and the Dana–Farber Cancer Institute. His first few papers were on the cloning of fat-cell selective mRNAs. A few years later, Spiegelman and his colleagues found that the adipose tissues express TNF and other cytokines in rodent and human obesity. This was the first indication that obesity is characterized by a low level inflammation in the fat tissue. In 1994, Spiegelman and his colleagues uncovered the role of PPAR-gamma in fat production, which they believed could lead to the production of new fat cells. Then, they displayed that the C/EBP path in cells could be knocked out and PPAR could still produce fat cells. As a result of these discoveries, Spiegelman was the recipient of Heinrich Wieland Prize in 1997. Two years following the original discovery, Spiegelman and colleagues discovered a transcriptional coactivator called PGC-1 alpha and a sister gene he named PGC-1 beta in 2002. PGC1a is a powerful regulator of mitochondrial biogenesis in brown fat, muscle and other tissues. PGC1a is also induced in muscle with exercise and promotes some of the cellular and molecular benefits of exercise. As a result of these accomplishments, Spiegelman was elected to the American Academy of Arts and Sciences and the National Academy of Sciences.Since 2008, Spiegelman has been the Stanley J. Korsmeyer Professor of Cell Biology and Medicine at the Dana–Farber Cancer Institute and Harvard Medical School, and Director of the Center for Metabolism and Chronic Disease at the Dana-Farber. In these roles, he identified both parts of a molecular switch that normally causes some immature muscle cells in the embryo to become brown fat cells. As a result, his team showed that they could engineer mouse and human cells to produce brown fat. Spiegelman and colleagues later identified PRDM16 as a crucial factor in brown fat development and the browning of white fat in 2007. His research team showed that this molecule controlled a transcriptional switch between muscle cells and brown fat cells in 2008. These studies led to the identification of beige fat cells (20120), another energy-burning but genetically distinct fat cell in mouse and adult humans.In 2012, Spiegelman and colleagues discovered the myokine irisin (2012) and further demonstrated that this hormone was produced in humans and increased during exercise. As a result of his research, Spiegelman received the Frederick Banting Medal of the American Diabetes Association in 2012 and the Manpei Suzuki Prize in 2013. The following year, he also earned an induction into the National Academy of Medicine and Belgium's InBev-Baillet Latour Prize. Later on it was discovered by other researchers, that the methods used to detect irisin used unspecific antibodies and the results could not be reproduced by other research groups.During the COVID-19 pandemic, Spiegelman was the recipient of the 2021 Albert Renold Award from the American Diabetes Association. He received the award as "an individual whose career is distinguished by outstanding achievements in the training and mentorship of diabetes research scientists and in the development of communities of scientists to enhance diabetes research." References External links Bruce M. Spiegelman publications indexed by Google Scholar . Discover the Bruce Spiegelman popular books. Find the top 100 most popular Bruce Spiegelman books.

Best Seller Bruce Spiegelman Books of February 2023

Dream Psychology e-book Download

Dream Psychology

Sigmund FreudNovember 1, 1899Get

An Apple Books Classic edition. Written by the founding father of psychoanalysis, Sigmund Freud’s 1899 book is the definitive text on learning to interpret dreams. Freud’s groundbreaking...

Herbs and Homicide e-book Download

Herbs and Homicide

Carly WinterJune 9, 2022Get

5 stars, Liz Konkel of Readers' Favorite: The story has an upbeat tone that is typical of the cozy genre though Winter adds a unique quality to it through the use of herbs. The characte...

Reckless at Heart e-book Download

Reckless at Heart

Zoe YorkJune 2, 2020Get

He's a grumpy silver fox who's about to become a grandfather, and she's the sunshiny young midwife who wants babies of her own…   Owen Kincaid knows how hard it is to have a kid when ...

I Have a Secret e-book Download

I Have a Secret

Cheryl BradshawApril 25, 2012Get

"The ending is a complete surprise!" - Reader  Doug Ward has been running from his past for twenty years. But after his fourth whisky of the night, his steely resolve has started to cra...

Meditations e-book Download

Meditations

Emperor of Rome Marcus AureliusDecember 25, 2008Get

Meditations is a series of personal writings by Marcus Aurelius, Roman Emperor 161–180 CE, setting forth his ideas on Stoic philosophy.

Risking Millions e-book Download

Risking Millions

Lexy TimmsAugust 24, 2021Get

Love is not something you protect. It's something you risk. Daniel Connor has a problem. A big one. Even though his company is a billion-dollar success in the hospitality industry, he's...

Hunting Season e-book Download

Hunting Season

Kate RudolphApril 5, 2021Get

This werewolf will protect his mate. Owen has one job: keep Stasia from being abducted. Easier said than done when his fiercely independent client tries to fire him the moment they meet. His...

Dirty Wild Sultan - A Steamy Marriage of Convenience Royal Romance e-book Download

Dirty Wild Sultan - A Steamy Marriage of Convenience Royal Romance

Mahi MistryJuly 7, 2022Get

He is my only chance at freedom. She is the daughter of my enemy. Will their love survive? Zain As the Sultan of one of the most powerful country in Middle-East, I need to find my Sultana. B...

How to Think Bigger: Aim Higher, Get More Motivated, and Accomplish Big Things e-book Download

How to Think Bigger: Aim Higher, Get More Motivated, and Accomplish Big Things

Martin MeadowsAugust 4, 2015Get

How to Get More Motivated, Set Bigger Goals, and Achieve More by Thinking Bigger Have you ever wondered what separates people who think bigger from people who set their bar low? What makes o...

Apple Watch User Guide e-book Download

Apple Watch User Guide

Apple Inc.September 16, 2021Get

Here’s everything you need to know about Apple Watch and the Apple Watch app on iPhone, straight from Apple. This definitive guide helps you get started using Apple Watch with watchOS 8 an...

Words of Wisdom - 100 Inspirational Quotations e-book Download

Words of Wisdom - 100 Inspirational Quotations

Various AuthorsDecember 17, 2012Get

From the world’s greatest thinkers across the centuries, Words of Wisdom is a delightful collection of advice and insight.  With a quotation for every situation, flick through the pag...

Pride and Prejudice e-book Download

Pride and Prejudice

Jane AustenJanuary 28, 1813Get

An Apple Books Classic edition. Jane Austen’s beloved classic opens with this witty and very memorable line: “It is a truth universally acknowledged, that a single man in possession of a...

The Boyfriend Effect e-book Download

The Boyfriend Effect

Kendall RyanOctober 13, 2020Get

A sexy new series of standalone romances from New York Times bestselling author Kendall Ryan.  I’m not boyfriend material. If a trail of broken hearts and a piss-poor record of failed...

Dead Before Dinner e-book Download

Dead Before Dinner

Kat BellemoreJuly 31, 2022Get

Green chile has never been more dangerous.   Psychologist Maddie Swallows’ decision to return to New Mexico seemed like a good idea at the time, considering the divorce and her two te...

Let's Taco Bout It e-book Download

Let's Taco Bout It

Matthew RyanOctober 1, 2014Get

Mr Taco is feeling sad, it’s not easy being a little taco when everything around you is so BIG! Luckily, Patrick has a few ideas to help his friend... ————  NOT YOUR REGULAR S...

Complicate Me: Reid & Sienna #1 e-book Download

Complicate Me: Reid & Sienna #1

Claire RayeJuly 8, 2020Get

Complicate Me is book one of Reid and Sienna’s duet and book one in the Hawthorn Hills Duet Series. A two-part, angst-filled, slow-burn, epic love story. Complicate Me must be read before ...

Fat Cat Finds a Home e-book Download

Fat Cat Finds a Home

Michelle SmithFebruary 20, 2015Get

After ten years of love from her previous owner, poor Fat Cat finds herself alone and looking for a new home. Will she ever leave the adoption shelter? Even at ten years old, Fat Cat still h...

Seascapes and Vegas Mistakes e-book Download

Seascapes and Vegas Mistakes

Kay LyonsApril 18, 2022Get

When a Las Vegas prank turns into an accidental and very legal marriage, Isabel Shipley is dead set on getting a discreet and hasty divorce. The last thing the struggling artist wants is to ...

Today I Am Mad e-book Download

Today I Am Mad

Michael GordonSeptember 7, 2020Get

Kids feel emotions in big ways! Here's a great story for helping kids manage their feelings. * Help children learn to identify and regulate their ...

Moby Dick e-book Download

Moby Dick

Herman MelvilleOctober 17, 1851Get

An Apple Books Classic edition. Herman Melville’s classic begins with one of the most famous opening lines in world literature: “Call me Ishmael.” Moby Dick was a commercial failure wh...

The Chronicles of Narnia Complete 7-Book Collection e-book Download

The Chronicles of Narnia Complete 7-Book Collection

C. S. LewisDecember 9, 2022Get

The Chronicles of Narnia Complete 7-Book Collection includes: The Lion, the Witch and the Wardrobe (1950) Prince Caspian (1951) The Voyage of the Dawn Treader (1952) The Silver Chair (1953) ...

Brant e-book Download

Brant

Jodi BasyeFebruary 14, 2022Get

He's a cranky cowboy trying to save the family ranch. She's a freelance journalist hoping to get a full-time writing gig. What she writes could either make or break him. Brant Cross feels re...

Worth Billions e-book Download

Worth Billions

Lexy TimmsJune 4, 2018Get

Small towns are for small minds. I left for college and never looked back.  Ensconced in my luxurious, and lucrative, vineyard, I barely ever spare a thought for my old life. Until I go...

Curvy Attraction (Aiden & Cecelia) e-book Download

Curvy Attraction (Aiden & Cecelia)

Christa WickOctober 11, 2019Get

“Ride with me.” Three simple words. A seemingly perfect solution after my car breaks down. So why am I so nervous about this? Sure, I’ve harbored the biggest crush on him for over a de...

For Now and Forever (The Inn at Sunset Harbor—Book 1) e-book Download

For Now and Forever (The Inn at Sunset Harbor—Book 1)

Sophie LoveAugust 16, 2016Get

“Sophie Love's ability to impart magic to her readers is exquisitely wrought in powerfully evocative phrases and descriptions….FOR NOW AND FOREVER is the perfect romance or beach read, w...

What I Like About You e-book Download

What I Like About You

Kait NolanJuly 19, 2019Get

A horse-whispering loner After years as an Army Ranger, Sebastian Donnelly is content to be left alone with his horses. He's better with them than with...people. But that changes when his bo...

Wuthering Heights e-book Download

Wuthering Heights

Emily BrontëNovember 30, 1847Get

An Apple Books Classic edition. If you’ve only ever seen Wuthering Heights on screen, you may have an image of Catherine and Heathcliff as the ultimate star-crossed lovers. But that’s ju...

Girl, Alone (An Ella Dark FBI Suspense Thriller—Book 1) e-book Download

Girl, Alone (An Ella Dark FBI Suspense Thriller—Book 1)

Blake PierceDecember 16, 2020Get

FBI Agent Ella Dark has studied serial killers from the time she could read, devastated by the murder of her own sister. With her photographic memory, she has obtained an encyclopedic knowle...

Severance e-book Download

Severance

AnonymousMarch 18, 2022Get

When does the cost of staying silent become greater than the price of speaking up? A desperate woman risks everything to expose the sinister company at the heart of Severance , the thrilling...

The Wonderful Wizard of Oz e-book Download

The Wonderful Wizard of Oz

L. Frank BaumMay 17, 1900Get

An Apple Books Classic edition. You’ve seen the iconic 1939 movie, but do you know about the talking field mice, the Winkies, and the Witch of the North that appear in the original book? L...

Law of Attraction e-book Download

Law of Attraction

Jordan HollisAugust 29, 2018Get

How to Finally Overcome the Hurdles of Manifesting Proven, effective and enjoyable ways to help you manifest faster… Right now, think of something that makes you successful. If you have so...

The Missing Ones e-book Download

The Missing Ones

Patricia GibneyMarch 16, 2017Get

The hole they dug was not deep. A white flour bag encased the little body. Three small faces watched from the window, eyes black with terror.   The child in the middle spoke without tur...

Stealth e-book Download

Stealth

Sarah PeisApril 28, 2022Get

Some mistakes are worth repeating. Freya Olysses loves her quiet life in the sleepy little town of Ferguson. She's made a home where she least expected to. Until her past catches up with her...

How to Find Peace e-book Download

How to Find Peace

Beau NortonSeptember 23, 2015Get

Shatter the Illusions and Discover the Truth To 'know about' something is very different from KNOWING it. Perhaps you have some spiritual knowledge, but how often do you experience ...

Seduction Island e-book Download

Seduction Island

Autumn GazeNovember 30, 2022Get

You cannot escape the reality of tomorrow by evading it today… Ethan Mitchell flees New York to Oahu to escape a family scandal. He doesn't want to be a part of it. He ends up meeting Ava ...

Eternal e-book Download

Eternal

W.J. MayJanuary 15, 2018Get

She will fight for what is hers. When the king is murdered, Katerina, his only daughter, must flee for her life. She finds herself on a strange and dangerous path. Alone for the first time, ...

The Next Girl e-book Download

The Next Girl

Carla KovachApril 2, 2018Get

IF YOU ONLY READ ONE BOOK THIS YEAR, MAKE IT THE NEXT GIRL... You thought he’d come to save you. You were wrong. ‘ Absolutely the best thriller I’ve read this year! ’ Goodreads Revie...

Undone (A Cora Shields Suspense Thriller—Book 1) e-book Download

Undone (A Cora Shields Suspense Thriller—Book 1)

Blake PierceOctober 11, 2022Get

In this action-packed mystery thriller by #1 bestselling author Blake Pierce, Cora Shields, 30, former Navy Seal turned FBI Special Agent, will stop at nothing to catch a killer— but she i...

Stop Procrastinating & Overthinking: Learn The Mind Hacks To Cure Your Procrastination Habit And Improve Your Perseverance To Overcome Laziness. Eliminate Negative Thoughts And Stop Worrying e-book Download

Stop Procrastinating & Overthinking: Learn The Mind Hacks To Cure Your Procrastination Habit And Improve Your Perseverance To Overcome Laziness. Eliminate Negative Thoughts And Stop Worrying

Sebastian GoodwinMarch 25, 2021Get

"I TRIED EVERYTHING ELSE, BUT IT'S STILL A NEVER-ENDING BATTLE…" Everybody knows that procrastination is the biggest waste of time – I am talking about those moments when you imagine wha...

Steal My Heart e-book Download

Steal My Heart

Savannah KadeMarch 24, 2020Get

Clark is what she needs, but Walker is what she wants… Armed with a checklist and a solid understanding of the kind of partner she needs, Cara Larkin has waited patiently for Mr. Right to ...

10-Minute Social Psychology e-book Download

10-Minute Social Psychology

Albert RutherfordJune 7, 2020Get

Would you like to instantly catch people's thoughts, emotions, motivations, and intentions through mere observation? If yes, you've come to the right place!  10-Minute So...

Habits e-book Download

Habits

Ronald A. ValentinoJanuary 31, 2016Get

Want to learn how to be part of the 5% that seem to get everything they want?  Look no further this book has the answer that will completely transform your life by teaching you the tech...

Explicit Instruction e-book Download

Explicit Instruction

Scarlett FinnJune 24, 2014Get

Enemies to lovers: Held captive by a dirty-talking alpha. "I wouldn't do that if I were you." Lost, Flick walks into a nightmare. More terrifying than the evil that captured her, a looming s...

How to Win Friends and Influence People e-book Download

How to Win Friends and Influence People

Dale CarnegieJuly 7, 2022Get

How to Win Friends and Influence People is a self-help book written by Dale Carnegie, first published in 1936. Over 30 million copies have been sold worldwide, making it one of the best-sell...

Tempting Levi e-book Download

Tempting Levi

Jules BarnardJune 6, 2017Get

Off-limits never looked so tempting... Levi Cade’s firefighting career burned up after an accident on the job. Then is father died and left him in charge of the family’s multimillion-dol...

The Very Hungry Caterpillar Library Books 1.1 e-book Download

The Very Hungry Caterpillar Library Books 1.1

Eric CarleMay 24, 2017Get

This is the series of The Very Hungry Caterpillar Little Learning Library Books. This book with Audio has been created as a university project for my last year. I have created lyrics and mus...

Taking a Risk e-book Download

Taking a Risk

Lexy TimmsMarch 16, 2019Get

Divorced, childless, and jobless at 30. My younger self had it all planned. I would be married by 22—check. Have the dream job after university—check. And a couple of kids to go with the...

Manifesting Abundance: How to Manifest Your Desires Using the Law of Attraction e-book Download

Manifesting Abundance: How to Manifest Your Desires Using the Law of Attraction

Beau NortonSeptember 26, 2015Get

Did you know that up to 95% of the people that attempt to use the law of attraction to manifest their desires see no noticeable results? The truth is that most people fail to use the law of ...

Become A Better Version of Yourself e-book Download

Become A Better Version of Yourself

Ben LeightonFebruary 22, 2015Get

This ebook contains golden nuggets on how to motivate, inspire and improve your current situation. It encompasses the holistic view of self improvement from mental& emotional wellbeing, ...

Nowhere Safe (A Harley Cole FBI Suspense Thriller—Book 1) e-book Download

Nowhere Safe (A Harley Cole FBI Suspense Thriller—Book 1)

Kate BoldSeptember 1, 2022Get

“This is an excellent book… When you start reading, be sure you don’t have to wake up early!” —Reader review for The Killing Game FBI BAU special agent Harley Cole, as brilliant as...

Best Seller Bruce Spiegelman Audio Books of February 2023

Lessons in Chemistry: A Novel (Unabridged) audiobook
Lessons in Chemistry: A Novel (Unabridged)Bonnie Garmus$16.99

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The Guest List audiobook
The Guest ListLucy Foley$3.99

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All Good People Here: A Novel (Unabridged) audiobook
All Good People Here: A Novel (Unabridged)Ashley Flowers$14.99

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Extreme Ownership audiobook
Extreme OwnershipJocko Willink & Leif Babin$14.99

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Never Finished: Unshackle Your Mind and Win the War Within (Unabridged) audiobook
Never Finished: Unshackle Your Mind and Win the War Within (Unabridged)David Goggins$21.99

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Sapiens audiobook
SapiensYuval Noah Harari$16.99

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Traction: Get a Grip on Your Business (Unabridged) audiobook
Traction: Get a Grip on Your Business (Unabridged)Gino Wickman$17.99

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Star Wars: The Battle of Jedha (The High Republic) (Unabridged) audiobook
Star Wars: The Battle of Jedha (The High Republic) (Unabridged)George Mann$12.99

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Sam: A Novel (Unabridged) audiobook
Sam: A Novel (Unabridged)Allegra Goodman$14.99

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1984 audiobook
1984George Orwell$3.99

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Mad Honey: A Novel (Unabridged) audiobook
Mad Honey: A Novel (Unabridged)Jodi Picoult & Jennifer Finney Boylan$14.99

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Scars and Stripes (Unabridged) audiobook
Scars and Stripes (Unabridged)Tim Kennedy$16.99

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The Midnight Library: A Novel (Unabridged) audiobook
The Midnight Library: A Novel (Unabridged)Matt Haig$14.99

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The Alchemist audiobook
The AlchemistPaulo Coelho$14.99

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Verity (Unabridged) audiobook
Verity (Unabridged)Colleen Hoover$17.99

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The Last Wish audiobook
The Last WishAndrzej Sapkowski$19.99

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The Art of Seduction (Unabridged) : An Indispensible Primer on the Ultimate Form of Power audiobook
The Art of Seduction (Unabridged) : An Indispensible Primer on the Ultimate Form of PowerRobert Greene$19.99

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The Dawn of Everything audiobook
The Dawn of EverythingDavid Graeber & David Wengrow$4.99

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You Are a Badass® audiobook
You Are a Badass®Jen Sincero$14.99

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The Boys from Biloxi: A Legal Thriller (Unabridged) audiobook
The Boys from Biloxi: A Legal Thriller (Unabridged)John Grisham$16.99

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Think Like a Monk (Unabridged) audiobook
Think Like a Monk (Unabridged)Jay Shetty$14.99

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The Mountain is You: Transforming Self-Sabotage Into Self-Mastery audiobook
The Mountain is You: Transforming Self-Sabotage Into Self-MasteryBrianna Wiest$9.99

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The Tools: Transform Your Problems into Courage, Confidence, and Creativity (Unabridged) audiobook
The Tools: Transform Your Problems into Courage, Confidence, and Creativity (Unabridged)Phil Stutz & Barry Michels$12.99

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The Light We Carry: Overcoming in Uncertain Times (Unabridged) audiobook
The Light We Carry: Overcoming in Uncertain Times (Unabridged)Michelle Obama$14.99

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When You're Ready, This Is How You Heal audiobook
When You're Ready, This Is How You HealBrianna Wiest$9.99

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I'm Glad My Mom Died (Unabridged) audiobook
I'm Glad My Mom Died (Unabridged)Jennette McCurdy$12.99

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Myth America audiobook
Myth AmericaKevin M. Kruse & Julian E. Zelizer$22.99

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Never Split the Difference audiobook
Never Split the DifferenceChris Voss & Tahl Raz$19.99

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Girl, Forgotten (Unabridged) audiobook
Girl, Forgotten (Unabridged)Karin Slaughter$4.99

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Desert Star audiobook
Desert StarMichael Connelly$16.99

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